G137B_DANRE
ID G137B_DANRE Reviewed; 373 AA.
AC E7F594;
DT 26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=G protein-coupled receptor 137Ba;
GN Name=gpr137ba {ECO:0000312|ZFIN:ZDB-GENE-100721-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=31173907; DOI=10.1016/j.bone.2019.06.002;
RA Urso K., Caetano-Lopes J., Lee P.Y., Yan J., Henke K., Sury M., Liu H.,
RA Zgoda M., Jacome-Galarza C., Nigrovic P.A., Duryea J., Harris M.P.,
RA Charles J.F.;
RT "A role for G protein-coupled receptor 137b in bone remodeling in mouse and
RT zebrafish.";
RL Bone 127:104-113(2019).
RN [3]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=31036939; DOI=10.1038/s41556-019-0321-6;
RA Gan L., Seki A., Shen K., Iyer H., Han K., Hayer A., Wollman R., Ge X.,
RA Lin J.R., Dey G., Talbot W.S., Meyer T.;
RT "The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1
RT localization and activity.";
RL Nat. Cell Biol. 21:614-626(2019).
CC -!- FUNCTION: Lysosomal integral membrane protein that regulates the
CC localization and activity of mTORC1, a signaling complex promoting cell
CC growth in response to growth factors, energy levels, and amino acids
CC (By similarity). Interacts with Rag GTPases and increases the
CC lysosomial localization and activity of Rag GTPases and thereby
CC regulates mTORC1 translocation and activity in lysosome
CC (PubMed:31036939). Acts also as a negative regulator of osteoclast
CC activity (PubMed:31173907). May be involved in interleukin-4-induced M2
CC macrophage polarization (By similarity). {ECO:0000250|UniProtKB:O60478,
CC ECO:0000250|UniProtKB:Q8BNQ3, ECO:0000269|PubMed:31036939,
CC ECO:0000269|PubMed:31173907}.
CC -!- FUNCTION: Acts also as a negative regulator of osteoclast activity
CC (PubMed:31173907). May be involved in interleukin-4-induced M2
CC macrophage polarization (By similarity). {ECO:0000250|UniProtKB:Q8BNQ3,
CC ECO:0000269|PubMed:31173907}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:O60478};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Knockout zebrafish are viable and fertile and
CC display no obvious morphological defects as adults (PubMed:31173907,
CC PubMed:31036939). However deficient zebrafish have abnormal microglial
CC with expended lysosomes (PubMed:31036939). They also display increased
CC bone resorption (PubMed:31173907). {ECO:0000269|PubMed:31036939,
CC ECO:0000269|PubMed:31173907}.
CC -!- SIMILARITY: Belongs to the GPR137 family. {ECO:0000305}.
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DR EMBL; CU651583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001341229.1; XM_001341193.6.
DR AlphaFoldDB; E7F594; -.
DR STRING; 7955.ENSDARP00000037177; -.
DR PaxDb; E7F594; -.
DR Ensembl; ENSDART00000031858; ENSDARP00000037177; ENSDARG00000078448.
DR GeneID; 100001171; -.
DR KEGG; dre:100001171; -.
DR CTD; 100001171; -.
DR ZFIN; ZDB-GENE-100721-1; gpr137ba.
DR eggNOG; ENOG502QQ83; Eukaryota.
DR GeneTree; ENSGT00940000153986; -.
DR HOGENOM; CLU_050057_0_0_1; -.
DR InParanoid; E7F594; -.
DR OMA; WNISPQG; -.
DR OrthoDB; 1399303at2759; -.
DR PhylomeDB; E7F594; -.
DR TreeFam; TF329003; -.
DR PRO; PR:E7F594; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 13.
DR Bgee; ENSDARG00000078448; Expressed in intestine and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0046849; P:bone remodeling; IMP:ZFIN.
DR GO; GO:0045779; P:negative regulation of bone resorption; IMP:UniProtKB.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IMP:UniProtKB.
DR GO; GO:0150032; P:positive regulation of protein localization to lysosome; ISS:UniProtKB.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; ISS:UniProtKB.
DR GO; GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
DR GO; GO:0043087; P:regulation of GTPase activity; IMP:UniProtKB.
DR InterPro; IPR029723; GPR137.
DR PANTHER; PTHR15146; PTHR15146; 1.
PE 3: Inferred from homology;
KW Autophagy; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..373
FT /note="G protein-coupled receptor 137Ba"
FT /id="PRO_0000448976"
FT TOPO_DOM 1..15
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..84
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 85..105
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..176
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 177..197
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 214..234
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..268
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..373
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 373 AA; 42892 MW; F81E0C08031FB066 CRC64;
MQKDSLPTLS PAVPPYVMLG LTVAYTIFYC LLFVFVYVQL WLVLRYRHKR FSYQTVFLFL
CLLWAALRAL LFSFYFKNCV TANTLGPFCF WLLYCFPVCL QFFTLSLMNL YFAQVIFKAK
SKYSPELQKY RLPLYLLFLS ISLLFLLVNL TCALLVKINR ANTETVVLVR VTVNDSLFVL
CAVSLSLCLY RIAKMSLANI YLEAKGTSVC QVTLIGVTVV LLYSSRACYN LVVLALTKIK
SINSFDYDWY NVSDQADLKS TLGDAGYVVF GVILFVWELL PTSLVVYFFR VRKPTLDRSA
SVIPGHMFSS RAYFFDNPRR YDSDDDLAWS IIPQNIQASF TSDSYDWSCR NNSFTAYTEA
EESHLAPEEL NPY
