G137C_HUMAN
ID G137C_HUMAN Reviewed; 429 AA.
AC Q8N3F9; Q86SM2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Integral membrane protein GPR137C;
DE AltName: Full=Transmembrane 7 superfamily member 1-like 2 protein;
GN Name=GPR137C; Synonyms=TM7SF1L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-148.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-429, AND VARIANT ILE-248.
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=31036939; DOI=10.1038/s41556-019-0321-6;
RA Gan L., Seki A., Shen K., Iyer H., Han K., Hayer A., Wollman R., Ge X.,
RA Lin J.R., Dey G., Talbot W.S., Meyer T.;
RT "The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1
RT localization and activity.";
RL Nat. Cell Biol. 21:614-626(2019).
CC -!- FUNCTION: Lysosomal integral membrane protein that may regulate MTORC1
CC complex translocation to lysosomes. {ECO:0000269|PubMed:31036939}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:31036939};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the GPR137 family. {ECO:0000305}.
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DR EMBL; AL157971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY255590; AAO85102.1; -; mRNA.
DR EMBL; AL834372; CAD39035.1; -; mRNA.
DR CCDS; CCDS45106.1; -.
DR RefSeq; NP_001093122.1; NM_001099652.1.
DR AlphaFoldDB; Q8N3F9; -.
DR BioGRID; 129601; 5.
DR IntAct; Q8N3F9; 1.
DR MINT; Q8N3F9; -.
DR STRING; 9606.ENSP00000315106; -.
DR GlyGen; Q8N3F9; 1 site.
DR iPTMnet; Q8N3F9; -.
DR PhosphoSitePlus; Q8N3F9; -.
DR BioMuta; GPR137C; -.
DR DMDM; 158563844; -.
DR MassIVE; Q8N3F9; -.
DR PaxDb; Q8N3F9; -.
DR PeptideAtlas; Q8N3F9; -.
DR PRIDE; Q8N3F9; -.
DR ProteomicsDB; 71799; -.
DR Antibodypedia; 23869; 75 antibodies from 24 providers.
DR DNASU; 283554; -.
DR Ensembl; ENST00000321662.11; ENSP00000315106.6; ENSG00000180998.12.
DR GeneID; 283554; -.
DR KEGG; hsa:283554; -.
DR MANE-Select; ENST00000321662.11; ENSP00000315106.6; NM_001099652.2; NP_001093122.1.
DR UCSC; uc001wzu.4; human.
DR CTD; 283554; -.
DR GeneCards; GPR137C; -.
DR HGNC; HGNC:25445; GPR137C.
DR HPA; ENSG00000180998; Group enriched (brain, epididymis, retina).
DR neXtProt; NX_Q8N3F9; -.
DR OpenTargets; ENSG00000180998; -.
DR PharmGKB; PA143485483; -.
DR VEuPathDB; HostDB:ENSG00000180998; -.
DR eggNOG; ENOG502QQ83; Eukaryota.
DR GeneTree; ENSGT00940000153986; -.
DR InParanoid; Q8N3F9; -.
DR OMA; NGPMADT; -.
DR OrthoDB; 1399303at2759; -.
DR PhylomeDB; Q8N3F9; -.
DR TreeFam; TF329003; -.
DR PathwayCommons; Q8N3F9; -.
DR SignaLink; Q8N3F9; -.
DR BioGRID-ORCS; 283554; 26 hits in 1072 CRISPR screens.
DR ChiTaRS; GPR137C; human.
DR GenomeRNAi; 283554; -.
DR Pharos; Q8N3F9; Tdark.
DR PRO; PR:Q8N3F9; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8N3F9; protein.
DR Bgee; ENSG00000180998; Expressed in cerebellar hemisphere and 116 other tissues.
DR ExpressionAtlas; Q8N3F9; baseline and differential.
DR Genevisible; Q8N3F9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR InterPro; IPR029723; GPR137.
DR PANTHER; PTHR15146; PTHR15146; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..429
FT /note="Integral membrane protein GPR137C"
FT /id="PRO_0000304803"
FT TOPO_DOM 1..48
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 49..69
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..120
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 168..188
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..205
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 247..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..300
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 301..321
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..429
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 248
FT /note="V -> I (in dbSNP:rs762063)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_053880"
FT CONFLICT 239
FT /note="K -> KITGSHSFLWLNSTPLC (in Ref. 3; CAD39035)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 429 AA; 47075 MW; DD307DE80AF6B1C8 CRC64;
MRVSVPGPAA AAAPAAGREP STPGGGSGGG GAVAAASGAA VPGSVQLALS VLHALLYAAL
FAFAYLQLWR LLLYRERRLS YQSLCLFLCL LWAALRTTLF SAAFSLSGSL PLLRPPAHLH
FFPHWLLYCF PSCLQFSTLC LLNLYLAEVI CKVRCATELD RHKILLHLGF IMASLLFLVV
NLTCAMLVHG DVPENQLKWT VFVRALINDS LFILCAISLV CYICKITKMS SANVYLESKG
MSLCQTVVVG SVVILLYSSR ACYNLVVVTI SQDTLESPFN YGWDNLSDKA HVEDISGEEY
IVFGMVLFLW EHVPAWSVVL FFRAQRLNQN LAPAGMINSH SYSSRAYFFD NPRRYDSDDD
LPRLGSSREG SLPNSQSLGW YGTMTGCGSS SYTVTPHLNG PMTDTAPLLF TCSNLDLNNH
HSLYVTPQN
