G137C_MOUSE
ID G137C_MOUSE Reviewed; 423 AA.
AC E9Q343;
DT 26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=G protein-coupled receptor 137C;
GN Name=Gpr137c {ECO:0000312|MGI:MGI:1917963};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Lysosomal integral membrane protein that may regulate MTORC1
CC complex translocation to lysosomes. {ECO:0000250|UniProtKB:Q8N3F9}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8N3F9};
CC Multi-pass membrane protein {ECO:0000255}.
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DR EMBL; AC154575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS49464.1; -.
DR RefSeq; NP_081794.2; NM_027518.2.
DR AlphaFoldDB; E9Q343; -.
DR STRING; 10090.ENSMUSP00000120015; -.
DR iPTMnet; E9Q343; -.
DR PhosphoSitePlus; E9Q343; -.
DR PaxDb; E9Q343; -.
DR PRIDE; E9Q343; -.
DR ProteomicsDB; 373707; -.
DR Antibodypedia; 23869; 75 antibodies from 24 providers.
DR DNASU; 70713; -.
DR Ensembl; ENSMUST00000146150; ENSMUSP00000120015; ENSMUSG00000049092.
DR GeneID; 70713; -.
DR KEGG; mmu:70713; -.
DR UCSC; uc007tgl.2; mouse.
DR CTD; 283554; -.
DR MGI; MGI:1917963; Gpr137c.
DR VEuPathDB; HostDB:ENSMUSG00000049092; -.
DR eggNOG; ENOG502QQ83; Eukaryota.
DR GeneTree; ENSGT00940000153986; -.
DR HOGENOM; CLU_050057_1_0_1; -.
DR InParanoid; E9Q343; -.
DR OMA; NGPMADT; -.
DR OrthoDB; 1399303at2759; -.
DR PhylomeDB; E9Q343; -.
DR TreeFam; TF329003; -.
DR BioGRID-ORCS; 70713; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Gpr137c; mouse.
DR PRO; PR:E9Q343; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; E9Q343; protein.
DR Bgee; ENSMUSG00000049092; Expressed in medial geniculate body and 180 other tissues.
DR ExpressionAtlas; E9Q343; baseline and differential.
DR Genevisible; E9Q343; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; ISO:MGI.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR InterPro; IPR029723; GPR137.
DR PANTHER; PTHR15146; PTHR15146; 1.
PE 3: Inferred from homology;
KW Lysosome; Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..423
FT /note="G protein-coupled receptor 137C"
FT /id="PRO_0000448977"
FT TOPO_DOM 1..42
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 43..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..114
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 115..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 162..182
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..193
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 194..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 242..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..294
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 295..315
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..423
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 46417 MW; 52F89F4AABED9852 CRC64;
MRVSVSGPAA AAVPTAGREP STSGGGAVAA SGAAVPGSVQ LALSVLHALL YAALFAFAYL
QLWRLLLYRE RRLSYQSLCL FLCLAWAALR TTLFSAAFSL SGSLPLLRPP SRLHFFPHWL
LYCFPSCLQF STLCLLNLYL AEVICKVRCA TELDKHKILL HLGFILASLL FLAVNLTCAM
LVHGDVPENQ LKWTVFIRAL INDSLFILCA ISLVSYICKI TKMSSANVYL ESKGMSLCQT
VIVGSVVILL YSSRACYNLV VITISQDTLE SPFNYGWDNL SDKAQGEDGN GGDYIVFGMV
LFLWEHVPAW SVVLFFRAQR LNQNLAPAGM ISSHSYSSRA FFFDNPRRYD SDDDLPRLGN
SREGSLSNSQ TLGWYGTMTG CGGGTYTVTP PLNGPVTDTA PLLFTCSNLD IRNHHSLYVT
PQN
