ID   G1P_BPF1                Reviewed;         348 AA.
AC   P03657;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Gene 1 protein;
DE   AltName: Full=G1P;
GN   Name=I;
OS   Enterobacteria phage f1 (Bacteriophage f1).
OC   Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes;
OC   Tubulavirales; Inoviridae; Inovirus.
OX   NCBI_TaxID=10863;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6282703; DOI=10.1016/0378-1119(81)90059-7;
RA   Beck E., Zink B.;
RT   "Nucleotide sequence and genome organisation of filamentous bacteriophages
RT   f1 and fd.";
RL   Gene 16:35-58(1981).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6292494; DOI=10.1128/jvi.44.1.32-46.1982;
RA   Hill D.F., Petersen G.B.;
RT   "Nucleotide sequence of bacteriophage f1 DNA.";
RL   J. Virol. 44:32-46(1982).
RN   [3]
RP   INTERACTION WITH G4P.
RX   PubMed=10564514; DOI=10.1046/j.1365-2958.1999.01636.x;
RA   Feng J.N., Model P., Russel M.;
RT   "A trans-envelope protein complex needed for filamentous phage assembly and
RT   export.";
RL   Mol. Microbiol. 34:745-755(1999).
CC   -!- FUNCTION: Isoform G1P plays an essential role in phage assembly. It is
CC       required to increase the number of adhesion zones between the inner and
CC       outer membranes of the host cell. The extrusion of neo-synthesized
CC       phages occurs at these adhesion sites. May be involved with G4P in
CC       creating zone through which the phage assembled and extruded.
CC   -!- FUNCTION: Isoform G11P is also involved in phage assembly, probably
CC       playing a structural role in the formation of the phage assembly site.
CC   -!- SUBUNIT: Interacts with G4P; this interaction results in a complex that
CC       spans the inner an outer host membranes. {ECO:0000269|PubMed:10564514}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=G1P; Synonyms=Gene 1 protein;
CC         IsoId=P03657-1; Sequence=Displayed;
CC       Name=G11P; Synonyms=Gene 11 protein;
CC         IsoId=P03657-2; Sequence=VSP_037569;
CC   -!- SIMILARITY: Belongs to the inovirus G1P protein family. {ECO:0000305}.
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DR   EMBL; V00606; CAA23874.1; -; Genomic_DNA.
DR   EMBL; J02448; AAA32217.1; -; Genomic_DNA.
DR   PIR; C04262; Z1BPF1.
DR   TCDB; 3.A.13.1.1; the filamentous phage exporter (fphe) family.
DR   Proteomes; UP000002557; Genome.
DR   Proteomes; UP000241027; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0099045; P:viral extrusion; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008900; Zot_N.
DR   Pfam; PF05707; Zot; 1.
PE   1: Evidence at protein level;
KW   Alternative initiation; ATP-binding; Host membrane; Membrane;
KW   Nucleotide-binding; Transmembrane; Transmembrane helix; Viral extrusion;
KW   Viral release from host cell.
FT   CHAIN           1..348
FT                   /note="Gene 1 protein"
FT                   /id="PRO_0000098201"
FT   TRANSMEM        254..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..240
FT                   /note="Missing (in isoform G11P)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_037569"
SQ   SEQUENCE   348 AA;  39528 MW;  CAC72D5C92499A66 CRC64;
     MAVYFVTGKL GSGKTLVSVG KIQDKIVAGC KIATNLDLRL QNLPQVGRFA KTPRVLRIPD
     KPSISDLLAI GRGNDSYDEN KNGLLVLDEC GTWFNTRSWN DKERQPIIDW FLHARKLGWD
     IIFLVQDLSI VDKQARSALA ENVVYCRRLD RITLPFVGTL YSLITGSKMP LPKLHVGVVK
     YGDSQLSPTV ERWLYTGKNL YNAYDTKQAF SSNYDSGVYS YLTPYLSHGR YFKPLNLGQK
     MKLTKIYLKK FSRVLCLAIG FASAFTYSYI TQPKPEVKKV VSQTYDFDKF TIDSSQRLNL
     SYRYVFKDSK GKLINSDDLQ KQGYSLTYID LCTVSIKKGN SNEIVKCN