ID   G1P_BPIF1               Reviewed;         353 AA.
AC   O80299;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Gene 1 protein;
DE   AltName: Full=G1P;
GN   Name=I;
OS   Escherichia phage If1 (Bacteriophage If1).
OC   Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes;
OC   Tubulavirales; Inoviridae; Infulavirus.
OX   NCBI_TaxID=10868;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hill D.F., Hughes G., McNaughton J.C., Stockwell P.A., Petersen G.B.;
RT   "DNA sequence of the filamentous coliphage If1.";
RL   Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Isoform G1P plays an essential role in phage assembly. It is
CC       required to increase the number of adhesion zones between the inner and
CC       outer membranes of the host cell. The extrusion of neo-synthesized
CC       phages occurs at these adhesion sites. May be involved with G4P in
CC       creating zone through which the phage assembled and extruded (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: Isoform G11P is also involved in phage assembly, probably
CC       playing a structural role in the formation of the phage assembly site.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with G4P; this interaction results in a complex that
CC       spans the inner an outer host membranes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=G1P; Synonyms=Gene 1 protein;
CC         IsoId=O80299-1; Sequence=Displayed;
CC       Name=G11P; Synonyms=Gene 11 protein;
CC         IsoId=O80299-2; Sequence=VSP_037572;
CC   -!- SIMILARITY: Belongs to the inovirus G1P protein family. {ECO:0000305}.
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DR   EMBL; U02303; AAC62157.1; -; Genomic_DNA.
DR   RefSeq; NP_047358.1; NC_001954.1. [O80299-1]
DR   GeneID; 1261857; -.
DR   KEGG; vg:1261857; -.
DR   Proteomes; UP000001833; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0099045; P:viral extrusion; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008900; Zot_N.
DR   Pfam; PF05707; Zot; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; ATP-binding; Host membrane; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW   Viral extrusion; Viral release from host cell.
FT   CHAIN           1..353
FT                   /note="Gene 1 protein"
FT                   /id="PRO_0000098204"
FT   TRANSMEM        254..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..240
FT                   /note="Missing (in isoform G11P)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_037572"
SQ   SEQUENCE   353 AA;  39990 MW;  BB8CB367CCFA949E CRC64;
     MAVYVVTGKL GAGKTLVAVG KIQDKIVSGC RVATNLDLRI HKLPRVGIFA KSPDVIRIPD
     KPSLDDLLAI GRGNNSYDEN KNGLLVLDEC GTWFNSRSWA DKERQSVINW FLHARKLGWD
     IIFLIQDLSI MDKQARVALA EHVVYCRRLD KITIPFIGSI YSVITGSKLP LPKVHVGIVK
     YGDSPQSMTV ERWTYTGRDL YAAYDTKQAF SDAYEHSSFS YLTPYLSHGR YAVKRDATFY
     MRLTRIYLKK YSRVLCLFCG FVSAFTYLSL SKPEATPQIK PVTTQIITSR YKPSELRITT
     SYRMGNAVGF EFMDAKKQKI ASDDLIKDGF RMVYITPCSV ELIKDGKHEK VTC