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G1P_BPIKE
ID   G1P_BPIKE               Reviewed;         365 AA.
AC   P03658;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Gene 1 protein;
DE   AltName: Full=G1P;
GN   Name=I;
OS   Salmonella phage IKe (Bacteriophage IKe).
OC   Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes;
OC   Tubulavirales; Inoviridae; Lineavirus.
OX   NCBI_TaxID=10867;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3981635; DOI=10.1016/0022-2836(85)90322-5;
RA   Peeters B.P.H., Peters R.M., Schoenmakers J.G.G., Konings R.N.H.;
RT   "Nucleotide sequence and genetic organization of the genome of the N-
RT   specific filamentous bacteriophage IKe. Comparison with the genome of the
RT   F-specific filamentous phages M13, fd and f1.";
RL   J. Mol. Biol. 181:27-39(1985).
CC   -!- FUNCTION: Isoform G1P plays an essential role in phage assembly. It is
CC       required to increase the number of adhesion zones between the inner and
CC       outer membranes of the host cell. The extrusion of neo-synthesized
CC       phages occurs at these adhesion sites. May be involved with G4P in
CC       creating zone through which the phage assembled and extruded (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: Isoform G11P is also involved in phage assembly, probably
CC       playing a structural role in the formation of the phage assembly site.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with G4P; this interaction results in a complex that
CC       spans the inner an outer host membranes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=G1P; Synonyms=Gene 1 protein;
CC         IsoId=P03658-1; Sequence=Displayed;
CC       Name=G11P; Synonyms=Gene 11 protein;
CC         IsoId=P03658-2; Sequence=VSP_037573;
CC   -!- SIMILARITY: Belongs to the inovirus G1P protein family. {ECO:0000305}.
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DR   EMBL; X02139; CAA26075.1; -; Genomic_DNA.
DR   PIR; A04263; Z1BPIK.
DR   RefSeq; NP_040578.1; NC_002014.1. [P03658-1]
DR   GeneID; 1260889; -.
DR   KEGG; vg:1260889; -.
DR   Proteomes; UP000000372; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0099045; P:viral extrusion; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008900; Zot_N.
DR   Pfam; PF05707; Zot; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; ATP-binding; Host membrane; Membrane;
KW   Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW   Viral extrusion; Viral release from host cell.
FT   CHAIN           1..365
FT                   /note="Gene 1 protein"
FT                   /id="PRO_0000098205"
FT   TRANSMEM        255..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..241
FT                   /note="Missing (in isoform G11P)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_037573"
SQ   SEQUENCE   365 AA;  41306 MW;  37469E48265E176D CRC64;
     MAVYVVTGKL GAGKTLVAVS RIQRTLAKGG IVATNLNLKL HHFPQVGRYA KQCRVMRIAD
     KPTLEDLESI GRGNLTYDES KNGLLVLDEC GTWFNSRNWS DKSRQPVIDW CLHARKLGWD
     IIFIIQDISL MDKQARDALA EHVVYCRRLD KLNIPIIGGL ISVLSGGRLP LPKVHFGIVK
     YGDNPQSLTV DKWVYTGTDL YAAYDTKQIF TSDREISPPY CPLSPYYTHG IFSVKRDAKY
     YMRMTKIYFK KMNRVFLMAS FLALGAACGI FYKSQAYSNQ LQHIQDNSKT SVISKTDQSA
     EILPRLSINS YSQMGYDVSV TFKDAKAKIY NSFDLIKDGY RVDIKDACHV TIVKKSYIQQ
     ITCEG
 
 
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