G2_VACCW
ID G2_VACCW Reviewed; 220 AA.
AC P68456; P21023; Q76ZU2;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 02-JUN-2021, entry version 45.
DE RecName: Full=Late transcription elongation factor G2;
DE AltName: Full=Protein G2;
GN OrderedLocusNames=VACWR080; ORFNames=G2R;
OS Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS WR)).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=10254;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Temperature-sensitive mutant;
RX PubMed=2024483; DOI=10.1016/0042-6822(91)90585-y;
RA Meis R.J., Condit R.C.;
RT "Genetic and molecular biological characterization of a vaccinia virus gene
RT which renders the virus dependent on isatin-beta-thiosemicarbazone (IBT).";
RL Virology 182:442-454(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA Wohlhueter R.;
RT "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT redundancy and an error rate of 0.16/10kb.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION WITH H5 AND A18, AND POSSIBLE IDENTIFICATION IN A COMPLEX WITH
RP A18 AND H5.
RX PubMed=9636370; DOI=10.1006/viro.1998.9166;
RA Black E.P., Moussatche N., Condit R.C.;
RT "Characterization of the interactions among vaccinia virus transcription
RT factors G2R, A18R, and H5R.";
RL Virology 245:313-322(1998).
RN [4]
RP FUNCTION.
RX PubMed=17336362; DOI=10.1016/j.virol.2007.02.005;
RA Cresawn S.G., Prins C., Latner D.R., Condit R.C.;
RT "Mapping and phenotypic analysis of spontaneous isatin-beta-
RT thiosemicarbazone resistant mutants of vaccinia virus.";
RL Virology 363:319-332(2007).
RN [5]
RP REVIEW.
RX PubMed=12917449; DOI=10.1099/vir.0.18942-0;
RA Broyles S.S.;
RT "Vaccinia virus transcription.";
RL J. Gen. Virol. 84:2293-2303(2003).
CC -!- FUNCTION: Involved in postreplicative transcription elongation on
CC intermediate and late genes. {ECO:0000269|PubMed:17336362}.
CC -!- SUBUNIT: Interacts with H5 and A18. Might be part of a transcription
CC complex composed at least of G2, A18, and H5.
CC {ECO:0000269|PubMed:9636370}.
CC -!- INTERACTION:
CC P68456; P07242: VACWR103; NbExp=4; IntAct=EBI-7273347, EBI-7272435;
CC -!- SIMILARITY: Belongs to the chordopoxvirinae G2 family. {ECO:0000305}.
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DR EMBL; J03399; AAB59813.1; -; Genomic_DNA.
DR EMBL; AY243312; AAO89359.1; -; Genomic_DNA.
DR PIR; A39986; QQVZW1.
DR RefSeq; YP_232962.1; NC_006998.1.
DR IntAct; P68456; 2.
DR MINT; P68456; -.
DR DNASU; 3707536; -.
DR GeneID; 3707536; -.
DR KEGG; vg:3707536; -.
DR Proteomes; UP000000344; Genome.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR InterPro; IPR008446; Chordopox_G2.
DR Pfam; PF05796; Chordopox_G2; 1.
PE 1: Evidence at protein level;
KW Early protein; Elongation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..220
FT /note="Late transcription elongation factor G2"
FT /id="PRO_0000099525"
FT VARIANT 151
FT /note="G -> R (in strain: Temperature-sensitive mutant)"
SQ SEQUENCE 220 AA; 25744 MW; FA97B1E8F419D1A2 CRC64;
MPFRDLILFN LSKFLLTEDE ESLEIVSSLC RGFEISYDDL ITYFPDRKYH KYISKVFEHV
DLSEELSMEF HDTTLRDLVY LRLYKYSKCI RPCYKLGDNL KGIVVIKDRN IYIREANDDL
IEYLLKEYTP QIYTYSNERV PITGSKLILC GFSQVTFMAY TTSHITTNKK VDVLVSKKCI
DELVDPINYQ ILQNLFDKGS GTINKILRKI FYSVTGGQTP
