G32P1_HUMAN
ID G32P1_HUMAN Reviewed; 272 AA.
AC Q8NGA4; Q8TDT1;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Putative G-protein coupled receptor GPR32P1;
DE AltName: Full=G-protein coupled 32 pseudogene;
DE AltName: Full=G-protein coupled 32 pseudogene 1;
DE AltName: Full=G-protein coupled receptor GPCR39;
DE Short=hGPCR39;
GN Name=GPR32P1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-272.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 29-272.
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. In contrast to other
CC members of the family, it is shorter at the C-terminus and lacks the
CC last 2 transmembrane regions. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06137.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BC066878; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AB065922; BAC06137.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB083621; BAB89334.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8NGA4; -.
DR SMR; Q8NGA4; -.
DR GlyGen; Q8NGA4; 2 sites.
DR BioMuta; HGNC:4488; -.
DR DMDM; 205785988; -.
DR PeptideAtlas; Q8NGA4; -.
DR PRIDE; Q8NGA4; -.
DR GeneCards; GPR32P1; -.
DR HGNC; HGNC:4488; GPR32P1.
DR neXtProt; NX_Q8NGA4; -.
DR PhylomeDB; Q8NGA4; -.
DR Pharos; Q8NGA4; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8NGA4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004875; F:complement receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004982; F:N-formyl peptide receptor activity; IBA:GO_Central.
DR GO; GO:0002430; P:complement receptor mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR000826; Formyl_rcpt-rel.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24225; PTHR24225; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..272
FT /note="Putative G-protein coupled receptor GPR32P1"
FT /id="PRO_0000349275"
FT TOPO_DOM 1..46
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 272 AA; 30291 MW; 0429AE51F860A701 CRC64;
MNGVSEGTRG CSDRQPGALT QGHSCSRKMN ASRCLSEEVG SLRPLTMAVL SASFVVGVLG
NGLVPWVTVF RMARTVSTVC FFHLALADFM LSLSLPILVY YIVSRQWLLG EWACKLYTGF
VFLTFSTSNC LLVLISVDRC ISVLYPVWAL NHRTEQRASW LAFGVWLLAA ALCSAHLKFR
TTRKWNGCMQ CYLQFNLENE TAQMWTQEVF GRQMAVIMAH FLLGFLGPLA IIGTCAHLIR
AKLLREGWVH ANRPKRLLLV LVSALSAGSH LT
