ID   G3BP_SCHPO              Reviewed;         434 AA.
AC   O94260;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Putative G3BP-like protein;
GN   Name=nxt3; ORFNames=SPBP8B7.11;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Probable scaffold protein that may be involved in mRNA
CC       transport. {ECO:0000305}.
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DR   EMBL; CU329671; CAA21796.1; -; Genomic_DNA.
DR   PIR; T40805; T40805.
DR   RefSeq; NP_596518.1; NM_001022439.2.
DR   AlphaFoldDB; O94260; -.
DR   SMR; O94260; -.
DR   BioGRID; 277875; 12.
DR   IntAct; O94260; 1.
DR   STRING; 4896.SPBP8B7.11.1; -.
DR   iPTMnet; O94260; -.
DR   MaxQB; O94260; -.
DR   PaxDb; O94260; -.
DR   PRIDE; O94260; -.
DR   EnsemblFungi; SPBP8B7.11.1; SPBP8B7.11.1:pep; SPBP8B7.11.
DR   GeneID; 2541364; -.
DR   KEGG; spo:SPBP8B7.11; -.
DR   PomBase; SPBP8B7.11; nxt3.
DR   VEuPathDB; FungiDB:SPBP8B7.11; -.
DR   eggNOG; KOG0116; Eukaryota.
DR   HOGENOM; CLU_022209_2_1_1; -.
DR   InParanoid; O94260; -.
DR   PhylomeDB; O94260; -.
DR   PRO; PR:O94260; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0010494; C:cytoplasmic stress granule; EXP:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:1990861; C:Ubp3-Bre5 deubiquitination complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:1905538; F:polysome binding; EXP:PomBase.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0016579; P:protein deubiquitination; IBA:GO_Central.
DR   GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; ISO:PomBase.
DR   GO; GO:0034517; P:ribophagy; IBA:GO_Central.
DR   CDD; cd00780; NTF2; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR002075; NTF2_dom.
DR   InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR039539; Ras_GTPase_bind_prot.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR10693; PTHR10693; 1.
DR   Pfam; PF02136; NTF2; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54427; SSF54427; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50177; NTF2_DOMAIN; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   mRNA transport; Phosphoprotein; Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..434
FT                   /note="Putative G3BP-like protein"
FT                   /id="PRO_0000194802"
FT   DOMAIN          18..134
FT                   /note="NTF2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
FT   DOMAIN          315..386
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          141..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        390..406
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..427
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         145
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   434 AA;  47972 MW;  365B41597930BD35 CRC64;
     MTAENATLLE PVLGKDEIGW MFVQEYYTYL NKEPNRLHCF YTKKSTLIHG DEGESISLCH
     GQQEIHNKIL DLDFQNCKVL ISNVDSLASS NGGIVIQVLG EMSNKGKLSR KFAQTFFLAE
     QPNGYFVLND IFRFLREDVE EEEESPDAVE KEKKDVASEP YVNGVQSQEH LPSAKEEGHY
     QDPAATENNF ATAALISNET DSLNQATLAV PEEPVIQVTE ASVPSFVSQQ ENQLQDEALT
     SNSKNADAIG ASDANVATAP KSWADLIARN HPDVKSQASV SSTASTTGQT VKGVNADQTQ
     QPTAPYTQSN ELLETSVFVK NIPPETSDVS LKSAMSIFGP VKAIEFARRK GTAYVDFVNH
     ECVQLALNKK TLQINNATLN IEERRRLFSG KFNKSGDKKS NDNYNGMKRN FRKGNRGAFD
     GRSKEVTTSK KQNN