ID   3NBA_BOIDE              Reviewed;          47 AA.
AC   P0C603;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Boigatoxin-A {ECO:0000303|PubMed:15683871};
DE   Flags: Fragment;
OS   Boiga dendrophila (Mangrove snake) (Gold-ringed cat snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Colubridae; Colubrinae; Boiga.
OX   NCBI_TaxID=46286;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=12955733; DOI=10.1002/rcm.1148;
RA   Fry B.G., Wuster W., Ryan Ramjan S.F., Jackson T., Martelli P., Kini R.M.;
RT   "Analysis of Colubroidea snake venoms by liquid chromatography with mass
RT   spectrometry: evolutionary and toxinological implications.";
RL   Rapid Commun. Mass Spectrom. 17:2047-2062(2003).
RN   [2]
RP   FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=15683871; DOI=10.1016/j.toxicon.2004.11.003;
RA   Lumsden N.G., Fry B.G., Ventura S., Kini R.M., Hodgson W.C.;
RT   "Pharmacological characterisation of a neurotoxin from the venom of Boiga
RT   dendrophila (mangrove catsnake).";
RL   Toxicon 45:329-334(2005).
CC   -!- FUNCTION: This toxin may inhibit nicotinic acetylcholine receptor
CC       (nAChR). It has poorly reversible postsynaptic blocking activity in a
CC       chick muscle preparation and readily reversible inhibitory activity at
CC       a presynaptic site in the rat vas deferens prostatic segment most
CC       likely to prevent the release of neurotransmitters.
CC       {ECO:0000269|PubMed:15683871}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12955733}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:12955733}.
CC   -!- MASS SPECTROMETRY: Mass=8769; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:12955733};
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. Boigatoxin sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C603; -.
DR   SMR; P0C603; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Presynaptic neurotoxin;
KW   Pyrrolidone carboxylic acid; Secreted; Toxin.
FT   CHAIN           1..>47
FT                   /note="Boigatoxin-A"
FT                   /evidence="ECO:0000269|PubMed:12955733"
FT                   /id="PRO_0000313787"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..34
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        13..21
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        27..?
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   NON_TER         47
SQ   SEQUENCE   47 AA;  5259 MW;  EB1A410B791934F7 CRC64;
     QAIGLPHTAC IQCNRKTSSK CLSGQICLPY HMTCYTLYKP DENGELK