ID   G3PP_METJA              Reviewed;         228 AA.
AC   Q58832;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Glyceraldehyde 3-phosphate phosphatase {ECO:0000303|PubMed:25848029};
DE            EC=3.1.3.- {ECO:0000305|PubMed:25848029};
GN   OrderedLocusNames=MJ1437;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   FUNCTION, AND COFACTOR.
RX   PubMed=25848029; DOI=10.1073/pnas.1423570112;
RA   Huang H., Pandya C., Liu C., Al-Obaidi N.F., Wang M., Zheng L.,
RA   Toews Keating S., Aono M., Love J.D., Evans B., Seidel R.D.,
RA   Hillerich B.S., Garforth S.J., Almo S.C., Mariano P.S., Dunaway-Mariano D.,
RA   Allen K.N., Farelli J.D.;
RT   "Panoramic view of a superfamily of phosphatases through substrate
RT   profiling.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:E1974-E1983(2015).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-
CC       phosphate in vitro. {ECO:0000269|PubMed:25848029}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000269|PubMed:25848029};
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L77117; AAB99446.1; -; Genomic_DNA.
DR   PIR; D64479; D64479.
DR   RefSeq; WP_010870955.1; NC_000909.1.
DR   AlphaFoldDB; Q58832; -.
DR   SMR; Q58832; -.
DR   STRING; 243232.MJ_1437; -.
DR   DNASU; 1452341; -.
DR   EnsemblBacteria; AAB99446; AAB99446; MJ_1437.
DR   GeneID; 1452341; -.
DR   KEGG; mja:MJ_1437; -.
DR   eggNOG; arCOG02291; Archaea.
DR   HOGENOM; CLU_045011_8_3_2; -.
DR   InParanoid; Q58832; -.
DR   OMA; TYHNVKF; -.
DR   OrthoDB; 93004at2157; -.
DR   PhylomeDB; Q58832; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0050124; F:N-acylneuraminate-9-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR   GO; GO:0046380; P:N-acetylneuraminate biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006439; HAD-SF_hydro_IA.
DR   InterPro; IPR011950; HAD-SF_hydro_IA_CTE7.
DR   InterPro; IPR041492; HAD_2.
DR   InterPro; IPR023214; HAD_sf.
DR   Pfam; PF13419; HAD_2; 1.
DR   PRINTS; PR00413; HADHALOGNASE.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR02253; CTE7; 1.
DR   TIGRFAMs; TIGR01549; HAD-SF-IA-v1; 1.
DR   TIGRFAMs; TIGR01509; HAD-SF-IA-v3; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..228
FT                   /note="Glyceraldehyde 3-phosphate phosphatase"
FT                   /id="PRO_0000107329"
SQ   SEQUENCE   228 AA;  26064 MW;  C832F9F435ABC3FF CRC64;
     MIKGILFDLD DTLYNSSEFV EIARREAVKS MIDAGLNIDF EEAMNILNKI IKDKGSNYGK
     HFDDLVKAVL GKYDPKIITT GIITYHNVKV ALLRPYPHTI KTLMELKAMG LKLGVITDGL
     TIKQWEKLIR LGIHPFFDDV ITSEEFGLGK PHLEFFKYGL KRMGLKAEET VYVGDRVDKD
     IKPAKELGMI TVRILKGKYK DMEDDEYSDY TINSLQELVD IVKNLKKD