ALG13_CRYNJ
ID ALG13_CRYNJ Reviewed; 200 AA.
AC P0CN88; Q55YI6; Q5KLF2;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=UDP-N-acetylglucosamine transferase subunit ALG13;
DE EC=2.4.1.141;
DE AltName: Full=Asparagine-linked glycosylation protein 13;
GN Name=ALG13; OrderedLocusNames=CNB05490;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in protein N-glycosylation. Essential for the second
CC step of the dolichol-linked oligosaccharide pathway (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-
CC acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl
CC diphosphodolichol + UDP; Xref=Rhea:RHEA:23380, Rhea:RHEA-COMP:9519,
CC Rhea:RHEA-COMP:9520, ChEBI:CHEBI:15378, ChEBI:CHEBI:57269,
CC ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:58427;
CC EC=2.4.1.141;
CC -!- SUBUNIT: Heterodimer with ALG14 to form a functional enzyme.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 28 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAW41985.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AE017342; AAW41985.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_569292.1; XM_569292.1.
DR AlphaFoldDB; P0CN88; -.
DR SMR; P0CN88; -.
DR STRING; 5207.AAW41985; -.
DR PaxDb; P0CN88; -.
DR EnsemblFungi; AAW41985; AAW41985; CNB05490.
DR VEuPathDB; FungiDB:CNB05490; -.
DR eggNOG; KOG3349; Eukaryota.
DR InParanoid; P0CN88; -.
DR OrthoDB; 1575485at2759; -.
DR Proteomes; UP000002149; Chromosome 2.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0004577; F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR InterPro; IPR039042; Alg13-like.
DR InterPro; IPR007235; Glyco_trans_28_C.
DR PANTHER; PTHR12867; PTHR12867; 1.
DR Pfam; PF04101; Glyco_tran_28_C; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..200
FT /note="UDP-N-acetylglucosamine transferase subunit ALG13"
FT /id="PRO_0000215600"
SQ SEQUENCE 200 AA; 22241 MW; C24A865CF7DEA59B CRC64;
MAHPFTLLVT VGSTLFPSLT SHVLLPTFLS LLQSLGVQRL VVQYGRAELK LQDDVKQTLN
IDSQGDGIGV WSDNDGDRVR DEKQNGMVVE VMRFTNDFEG LVGKSDAVIS HAGSGSILTV
LRRAPPIPLL VVPNRSLMDD HQSELADALY KDGYVMVASV EDLEEKVQPF LKIWPSQAKL
FPETRKEVFR EVVDDLMGYD