ID   G3R_VAR67               Reviewed;         585 AA.
AC   Q76QY7;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Ankyrin repeat protein G3R;
GN   Name=G3R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=1666548;
RA   Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M.,
RA   Chizhikov V.E., Gutorov V.V., Safronov P.F., Pozdnyakov S.G.,
RA   Shelukhina E.M., Gashnikov P.V., Anjaparidze O.G., Sandakhchiev L.S.;
RT   "Creation of a clone library of fragments from the natural variola virus
RT   and study of the structural and functional organization of viral genes from
RT   a circle of hosts.";
RL   Dokl. Akad. Nauk SSSR 321:402-406(1991).
RN   [2]
RP   DOMAIN.
RX   PubMed=16025237; DOI=10.1007/s11262-005-1784-z;
RA   Mercer A.A., Fleming S.B., Ueda N.;
RT   "F-box-like domains are present in most poxvirus ankyrin repeat proteins.";
RL   Virus Genes 31:127-133(2005).
CC   -!- FUNCTION: May be involved in virus-host protein interaction through the
CC       ankyrin repeats and PRANC regions.
CC   -!- DOMAIN: Ankyrin repeats may mediate protein-protein interactions.
CC       {ECO:0000269|PubMed:16025237}.
CC   -!- DOMAIN: PRANC (Pox proteins Repeats of ANkyrin, C-terminal) region is
CC       found on many poxvirus ankyrin proteins, and is related to F-box motifs
CC       involved in protein-protein interactions.
CC       {ECO:0000269|PubMed:16025237}.
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DR   EMBL; X69198; CAA49136.1; -; Genomic_DNA.
DR   PIR; C36858; C36858.
DR   PIR; T28622; T28622.
DR   RefSeq; NP_042239.1; NC_001611.1.
DR   SMR; Q76QY7; -.
DR   GeneID; 1486426; -.
DR   KEGG; vg:1486426; -.
DR   Proteomes; UP000002060; Genome.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR018272; PRANC_domain.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF09372; PRANC; 1.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   4: Predicted;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..585
FT                   /note="Ankyrin repeat protein G3R"
FT                   /id="PRO_0000412982"
FT   REPEAT          66..98
FT                   /note="ANK 1"
FT   REPEAT          172..220
FT                   /note="ANK 2"
FT   REPEAT          224..256
FT                   /note="ANK 3"
FT   REPEAT          297..333
FT                   /note="ANK 4"
FT   REPEAT          336..365
FT                   /note="ANK 5"
FT   REGION          554..571
FT                   /note="PRANC/F-box-like"
SQ   SEQUENCE   585 AA;  69057 MW;  E471FE00AEB99A71 CRC64;
     MDEIVNIVRD SMWFIPNVFM DNGENDGHVS VNNVCHMYFA FFDVDTSSHL FKLVIKHCDL
     NKQLKCGMSP LHCYVMNTRF KPSVLKILLH NGVNNFDNKD NKGHIPLHHY LIYSLSIDNK
     VFDILTDPID DFSKSSDLLL CYLRYKFNGR LNYYVLYKLL TKGSDPNCVD EDGLTSLHYY
     CKHISAFHES NYYKSKSYTK MRAEKRFIYT IINHGANINA VTKIGNTPLH TYLQQYTKHS
     PRVVYALLSR GADTRIRNNF DCTPIMEYIK NDCVTGHILI MLLNWHEQKY GKLQKEEGHH
     LLYLFIKHNQ GYGSHAFNIL RYLLDRFDIQ KDEYYNTMTP LHTAFQNCNN NVASYLVYIG
     YDINLPTKDD KTVFDLVFEN RNILFNAGVI HNIIHHRLKV SLPMIKSLFY KMLEFSPYDD
     YYVKKIIAYC ILRDESFTEL HSKFCLNEDY KSVFMKNISF DKIDSIIKKC NWDISRLKDI
     QISDTNLYTV LRTEDIRYRT YLKAIHLDSH ISFPMYDDLI EQCHLSMERK SKLVDKVLNK
     LKSTIDGQSR LSYLPPEIIR NIITKLSDYH LNSMLYGKNH YKYYT