ID   G432_FUSSX              Reviewed;         382 AA.
AC   A0A6S6AAU0;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   02-DEC-2020, sequence version 1.
DT   03-AUG-2022, entry version 7.
DE   RecName: Full=Myb-like transcription factor {ECO:0000303|PubMed:32139880};
DE   AltName: Full=1233A biosynthesis cluster protein g432 {ECO:0000303|PubMed:32139880};
GN   Name=g432 {ECO:0000303|PubMed:32139880};
OS   Fusarium sp.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=29916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=RK97-94;
RX   PubMed=32139880; DOI=10.1038/s41429-020-0295-4;
RA   Kato S., Motoyama T., Uramoto M., Nogawa T., Kamakura T., Osada H.;
RT   "Induction of secondary metabolite production by hygromycin B and
RT   identification of the 1233A biosynthetic gene cluster with a self-
RT   resistance gene.";
RL   J. Antibiot. 73:475-479(2020).
CC   -!- FUNCTION: Transcription factor; part of the gene cluster that mediates
CC       the biosynthesis of 1233A, a natural compound known as an inhibitor of
CC       HMG-CoA synthase in the mevalonate pathway and with antibacterial and
CC       antifungal activities (PubMed:32139880). Involved in hygromycin B-
CC       induced transcriptional control of the cluster (PubMed:32139880).
CC       {ECO:0000269|PubMed:32139880}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:32139880}.
CC   -!- INDUCTION: Expression is increased upon exposure to hygromycin B.
CC       {ECO:0000269|PubMed:32139880}.
CC   -!- DISRUPTION PHENOTYPE: Impairs the ability to produce 1233A and 1233B.
CC       {ECO:0000269|PubMed:32139880}.
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DR   EMBL; LC516401; BBU37367.1; -; Genomic_DNA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00167; SANT; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 3.
DR   SMART; SM00717; SANT; 3.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51294; HTH_MYB; 2.
DR   PROSITE; PS50090; MYB_LIKE; 3.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..382
FT                   /note="Myb-like transcription factor"
FT                   /id="PRO_0000454631"
FT   DOMAIN          1..57
FT                   /note="Myb-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT   DOMAIN          58..108
FT                   /note="Myb-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT   DOMAIN          109..160
FT                   /note="Myb-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT   REGION          194..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..210
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..240
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   382 AA;  42157 MW;  CDF30F83178262B8 CRC64;
     MPRSPRRWTP EEDRVLLDKV KQLFSDGAKN DTTISWATVA NALPDRNNKD CRKRWSKITG
     AKKGSWSLSE DEQLLEGVQK YGRQWAMVAK GVETRSADQC AKRWQHCLDP SLDRSEWRSD
     QDARLVAAVR RYGTNWKDIK KFEFPKRSTT NLKNRHITLF RQRNKAPGAC PGSTETLGPG
     IDWWSMEQGM IDDMSMDASE DGDDAEDDQT PDSYTSISTS SFDDILGGSS SSPSAADTMT
     TASPDPYQYL LDWAVPSHAD LVQAATSYYP SLDGFLGSTY DHNAKIDSSL GRDANGGNFI
     PGFPTQTPSQ FESIDVSQIS DGIVSGEPSR QGASRECRAA SNVSSGPQMT LTIDNPDPQT
     MTGILEVLAK ANSKVTISMN RE