G45IP_BOVIN
ID G45IP_BOVIN Reviewed; 222 AA.
AC A1A4P4;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Growth arrest and DNA damage-inducible proteins-interacting protein 1;
DE AltName: Full=39S ribosomal protein L59, mitochondrial;
DE Short=MRP-L59;
GN Name=GADD45GIP1; Synonyms=MRPL59;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a negative regulator of G1 to S cell cycle phase
CC progression by inhibiting cyclin-dependent kinases. Inhibitory effects
CC are additive with GADD45 proteins but occurs also in the absence of
CC GADD45 proteins. Acts as a repressor of the orphan nuclear receptor
CC NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be
CC involved in the hormone-mediated regulation of NR4A1 transcriptional
CC activity. May play a role in mitochondrial protein synthesis.
CC {ECO:0000250|UniProtKB:Q8TAE8}.
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins. Interacts
CC with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1
CC AB domain. Interacts with ATAD3A and ATAD3B.
CC {ECO:0000250|UniProtKB:Q8TAE8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8TAE8}.
CC Nucleus {ECO:0000250|UniProtKB:Q8TAE8}. Note=Using N-terminally tagged
CC constructs, has been found in the nucleus. C-terminally tagged
CC constructs are targeted exclusively to mitochondria. This discrepancy
CC may be explained by masking of a potential N-terminal mitochondrial
CC targeting signal by the tag. {ECO:0000250|UniProtKB:Q8TAE8}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL64 family. {ECO:0000305}.
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DR EMBL; BC126785; AAI26786.1; -; mRNA.
DR RefSeq; NP_001073693.1; NM_001080224.2.
DR AlphaFoldDB; A1A4P4; -.
DR SMR; A1A4P4; -.
DR STRING; 9913.ENSBTAP00000020114; -.
DR PaxDb; A1A4P4; -.
DR PRIDE; A1A4P4; -.
DR GeneID; 504718; -.
DR KEGG; bta:504718; -.
DR CTD; 90480; -.
DR eggNOG; KOG4848; Eukaryota.
DR HOGENOM; CLU_102022_0_0_1; -.
DR InParanoid; A1A4P4; -.
DR OrthoDB; 1431395at2759; -.
DR TreeFam; TF323794; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005759; C:mitochondrial matrix; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 6.10.280.120; -; 1.
DR InterPro; IPR043035; Damage-induce-interact_sf.
DR InterPro; IPR018472; Damage-induce-interacting_prot.
DR PANTHER; PTHR31761; PTHR31761; 1.
DR Pfam; PF10147; CR6_interact; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Coiled coil; Mitochondrion; Nucleus; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..222
FT /note="Growth arrest and DNA damage-inducible proteins-
FT interacting protein 1"
FT /id="PRO_0000317428"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 144..213
FT /evidence="ECO:0000255"
FT MOTIF 184..200
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 137..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 222 AA; 25746 MW; F977BA0FCF07A50B CRC64;
MAAPVRQTRS LLGWVTTLGP GSRGYRAPPP PRRSREPWWP DPDDPLTPRW QLGPRYAAKQ
FARHGAASGV DPGSLWPSRE QLLELEAEER EWYPSLAVMQ ESLRVQQLAE EQKRQAREQL
IEECMAKMPQ MIENWRRQQQ ARREKAQADK ERRARLQAEA QERLGYHVDP RSARFQELLQ
DLEKQHRKRL KEEKQRKKKE ARAAAMAAAA AQDPADSETP DS