G45IP_RAT
ID G45IP_RAT Reviewed; 228 AA.
AC Q5XJW2;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Growth arrest and DNA damage-inducible proteins-interacting protein 1;
DE AltName: Full=39S ribosomal protein L59, mitochondrial;
DE Short=MRP-L59;
GN Name=Gadd45gip1; Synonyms=Mrpl59;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-181.
RC TISSUE=Retinal ganglion;
RA Farkas R.H., Qian J., Goldberg J.L., Quigley H.A., Zack D.J.;
RT "Gene expression profiling of highly purified rat retinal ganglion cells.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-228.
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a negative regulator of G1 to S cell cycle phase
CC progression by inhibiting cyclin-dependent kinases. Inhibitory effects
CC are additive with GADD45 proteins but occurs also in the absence of
CC GADD45 proteins. Acts as a repressor of the orphan nuclear receptor
CC NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be
CC involved in the hormone-mediated regulation of NR4A1 transcriptional
CC activity. May play a role in mitochondrial protein synthesis.
CC {ECO:0000250|UniProtKB:Q8TAE8}.
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins. Interacts
CC with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1
CC AB domain. Interacts with ATAD3A and ATAD3B.
CC {ECO:0000250|UniProtKB:Q8TAE8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8TAE8}.
CC Nucleus {ECO:0000250|UniProtKB:Q8TAE8}. Note=Using N-terminally tagged
CC constructs, has been found in the nucleus. C-terminally tagged
CC constructs are targeted exclusively to mitochondria. This discrepancy
CC may be explained by masking of a potential N-terminal mitochondrial
CC targeting signal by the tag. {ECO:0000250|UniProtKB:Q8TAE8}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL64 family. {ECO:0000305}.
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DR EMBL; CF977882; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC083178; AAH83178.1; -; mRNA.
DR RefSeq; NP_001093974.1; NM_001100504.1.
DR AlphaFoldDB; Q5XJW2; -.
DR SMR; Q5XJW2; -.
DR STRING; 10116.ENSRNOP00000004027; -.
DR iPTMnet; Q5XJW2; -.
DR PhosphoSitePlus; Q5XJW2; -.
DR jPOST; Q5XJW2; -.
DR PaxDb; Q5XJW2; -.
DR PRIDE; Q5XJW2; -.
DR Ensembl; ENSRNOT00000004027; ENSRNOP00000004027; ENSRNOG00000003011.
DR GeneID; 288916; -.
DR KEGG; rno:288916; -.
DR CTD; 90480; -.
DR RGD; 1309249; Gadd45gip1.
DR eggNOG; KOG4848; Eukaryota.
DR GeneTree; ENSGT00390000013719; -.
DR HOGENOM; CLU_102022_0_0_1; -.
DR InParanoid; Q5XJW2; -.
DR OMA; EQHIAEC; -.
DR OrthoDB; 1431395at2759; -.
DR PhylomeDB; Q5XJW2; -.
DR TreeFam; TF323794; -.
DR Reactome; R-RNO-5389840; Mitochondrial translation elongation.
DR Reactome; R-RNO-5419276; Mitochondrial translation termination.
DR PRO; PR:Q5XJW2; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000003011; Expressed in skeletal muscle tissue and 20 other tissues.
DR Genevisible; Q5XJW2; RN.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0097177; F:mitochondrial ribosome binding; ISO:RGD.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:1903862; P:positive regulation of oxidative phosphorylation; ISO:RGD.
DR Gene3D; 6.10.280.120; -; 1.
DR InterPro; IPR043035; Damage-induce-interact_sf.
DR InterPro; IPR018472; Damage-induce-interacting_prot.
DR PANTHER; PTHR31761; PTHR31761; 1.
DR Pfam; PF10147; CR6_interact; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Coiled coil; Mitochondrion; Nucleus; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..228
FT /note="Growth arrest and DNA damage-inducible proteins-
FT interacting protein 1"
FT /id="PRO_0000228622"
FT REGION 20..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 98..207
FT /evidence="ECO:0000255"
FT MOTIF 184..200
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 186..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 228 AA; 26467 MW; FE7D5DCEA1DA1B1E CRC64;
MAAPATRSRY LLRLTVTLGP RSRSYHAPPP PRRRPAPHWP DRENLMTPRW QLTPRYAAKQ
FGRHGAISGV PPASLWPSSE QLCELEAEER EWYPSLATMQ ESLRVQQQAA EARRQAREQH
IAECMAKMPQ MIENWRKQKR ERWEKIQADK ERRARLQAEA QEQLGYHVDP RSARFQELLQ
DLDKQQRKRL KEERQRQKKE ARIAAMASAE GQDSAEAQDS AASGKPSS
