ID   G59B_DROER              Reviewed;         587 AA.
AC   Q8I1F0;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Putative gustatory receptor 59b;
GN   Name=Gr59b {ECO:0000312|EMBL:AAO01017.1};
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1] {ECO:0000312|EMBL:AAO01017.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12537575; DOI=10.1186/gb-2002-3-12-research0086;
RA   Bergman C.M., Pfeiffer B.D., Rincon-Limas D.E., Hoskins R.A., Gnirke A.,
RA   Mungall C.J., Wang A.M., Kronmiller B., Pacleb J.M., Park S., Stapleton M.,
RA   Wan K.H., George R.A., de Jong P.J., Botas J., Rubin G.M., Celniker S.E.;
RT   "Assessing the impact of comparative genomic sequence data on the
RT   functional annotation of the Drosophila genome.";
RL   Genome Biol. 3:RESEARCH0086.1-RESEARCH0086.20(2002).
CC   -!- FUNCTION: Probable gustatory receptor which mediates acceptance or
CC       avoidance behavior, depending on its substrates. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily. Gustatory
CC       receptor (GR) family. Gr22e subfamily. {ECO:0000305}.
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DR   EMBL; AY190941; AAO01017.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8I1F0; -.
DR   eggNOG; ENOG502TATR; Eukaryota.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013604; 7TM_chemorcpt.
DR   PANTHER; PTHR21143; PTHR21143; 2.
DR   Pfam; PF08395; 7tm_7; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Receptor; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..587
FT                   /note="Putative gustatory receptor 59b"
FT                   /id="PRO_0000216521"
FT   TOPO_DOM        1..4
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        5..25
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..62
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        84..97
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..277
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        278..298
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        310..330
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        331..403
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        404..424
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        425..518
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        519..539
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        540..587
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   587 AA;  68958 MW;  E134D90C08E224D4 CRC64;
     MPSYMAFTPY IMFSTNYAAI AYILISRCYR DSMLLDLQRI TLEVNREMLR TGKKMNSLIR
     RMFFLKTFTL TYSCLSYILA VLVYQWRAQN WSNLFNGLLV NISLTILVVT TFFYFVSLMH
     VARGFDFVNQ QLEDIVSSQS MDLKKKAHEL RSLWALHSNL SNTARRINKH YGPQMLALRF
     DYFIFSVINC CIGTIYSNSD QESSFEKFFG SLLYWARSVD FFLNDYICNL VTEYQSQPKF
     FAPEGSMTNE LSSYLIYESS TRLDLLVCGL YPVNKAKWLE MVASIVVHSI MLFQFHLVMR
     GGYTTLFSRT YALLANIITL TMLPIVMWQV RSVFLAKRHY PQLILITNDI RYTVSFLIIL
     YTLLSRGFRD TALKEMQPLL LTLFREEKRC GYKGIDGVRR SLRILLFVKF FTLSWLCITD
     IIFLFYSSDA VIWVNIARFL FLSNTNNILE MVPMGYFLAL WHIARGFDCV NRRLDQIVKS
     KSTRDQKELQ HLWFLHTCLT KTALNINKIY APQMLATRFD HFVIGVIQAY WGAVFTFDLS
     TSFLWVVYGS VQYHVRSLDY YLIDYMCDVA VEYHDSARHS WSEKECY