ID   ALG14_RAT               Reviewed;         216 AA.
AC   Q6AY85;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=UDP-N-acetylglucosamine transferase subunit ALG14 homolog;
GN   Name=Alg14;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in protein N-glycosylation. Essential for the second
CC       step of the dolichol-linked oligosaccharide pathway. Anchors the
CC       catalytic subunit ALG13 to the ER (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with ALG13 to form a functional enzyme.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P38242}; Single-pass membrane protein
CC       {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:P38242}; Single-
CC       pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ALG14 family. {ECO:0000305}.
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DR   EMBL; BC079151; AAH79151.1; -; mRNA.
DR   RefSeq; NP_001014198.1; NM_001014176.2.
DR   AlphaFoldDB; Q6AY85; -.
DR   SMR; Q6AY85; -.
DR   STRING; 10116.ENSRNOP00000015355; -.
DR   PhosphoSitePlus; Q6AY85; -.
DR   PaxDb; Q6AY85; -.
DR   GeneID; 362031; -.
DR   KEGG; rno:362031; -.
DR   UCSC; RGD:1312003; rat.
DR   CTD; 199857; -.
DR   RGD; 1312003; Alg14.
DR   VEuPathDB; HostDB:ENSRNOG00000011528; -.
DR   eggNOG; KOG3339; Eukaryota.
DR   HOGENOM; CLU_064541_2_0_1; -.
DR   InParanoid; Q6AY85; -.
DR   OMA; GPGTCCI; -.
DR   OrthoDB; 1449763at2759; -.
DR   PhylomeDB; Q6AY85; -.
DR   TreeFam; TF105628; -.
DR   PRO; PR:Q6AY85; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000011528; Expressed in ovary and 20 other tissues.
DR   Genevisible; Q6AY85; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043541; C:UDP-N-acetylglucosamine transferase complex; IBA:GO_Central.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR013969; Oligosacch_biosynth_Alg14.
DR   PANTHER; PTHR12154; PTHR12154; 1.
DR   Pfam; PF08660; Alg14; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..216
FT                   /note="UDP-N-acetylglucosamine transferase subunit ALG14
FT                   homolog"
FT                   /id="PRO_0000265118"
FT   TOPO_DOM        1..3
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:P38242"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..216
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P38242"
SQ   SEQUENCE   216 AA;  23979 MW;  803B2963B4D10A58 CRC64;
     MVCVLTLAAS AGGLAVLLIV RLWAVLRSHP VTPRQSLGLL IVAGSGGHTA EILRLVGSLS
     GAYSPRHYVI AESDEMSAKK IHSLELARAQ NDSTTEHTEY YLHRIPRSRE VRQSWLSSVF
     TTLYSIWFSF PLVHRIKPDL VLCNGPGTCV PICVSALLLG ILGIKKVIIV YVESICRVET
     LSLSGKILWH LSDYFIVQWP TLKEKYPKSV YLGRIV