G6PI1_CLAAR
ID G6PI1_CLAAR Reviewed; 568 AA.
AC P54234;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Glucose-6-phosphate isomerase, cytosolic 1;
DE Short=GPI;
DE EC=5.3.1.9;
DE AltName: Full=Phosphoglucose isomerase;
DE Short=PGI;
DE AltName: Full=Phosphohexose isomerase;
DE Short=PHI;
GN Name=PGIC1;
OS Clarkia arcuata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Onagraceae; Onagroideae; Onagreae; Clarkia.
OX NCBI_TaxID=50280;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Population LDG 8615;
RX AGRICOLA=IND20535960; DOI=10.2307/2419558;
RA Gottlieb L.D., Ford V.S.;
RT "Phylogenetic relationships among the sections of Clarkia (Onagraceae)
RT inferred from the nucleotide sequences of PgiC.";
RL Syst. Bot. 21:1-18(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9;
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X89395; CAA61575.1; -; Genomic_DNA.
DR AlphaFoldDB; P54234; -.
DR SMR; P54234; -.
DR UniPathway; UPA00109; UER00181.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR Gene3D; 1.10.1390.10; -; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR023096; G6P_Isomerase_C.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; PTHR11469; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase.
FT CHAIN 1..568
FT /note="Glucose-6-phosphate isomerase, cytosolic 1"
FT /id="PRO_0000180552"
FT ACT_SITE 360
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 391
FT /evidence="ECO:0000250"
FT ACT_SITE 516
FT /evidence="ECO:0000250"
SQ SEQUENCE 568 AA; 62659 MW; 1F9800426D8BC169 CRC64;
MASPALISET EAWKDLKAHL EGIKRTHLRE LMGDTERCQS MMVEFDNIFL DYSRQQASSD
TINKLYKLAD AAHLKQKIDR MYNGDHINST ENRSVLHVAL RAPRNSAICS DGKNVVPDVW
NVLDKIKDFS DRVRNGSWIG ATGKKLKDVI AVGIGGSFLG PLFVHTALQT DPEASKNARG
RELRFLANVD PIDVARNISG LNPESTLVVV VSKTFTTAET MLNARTLREW ISSALGPSAV
AKHMVAVSTN LPLVEKFGID PINAFAFWDW VGGRYSVCSA VGVLPLSLQY GFAVVEKFLQ
GAHSIDQHFS SASFEKNIPV LLGLLSVWNV SFLGYPARAI LPYSQALEKL APHIQQVSME
SNGKGVSIDG LPLPFESGEI DFGEPGTNGQ HSFYQLIHQG RVIPCDFIGV VKSQQPVYLK
GEVVNNHDEL MSNFFAQPDA LAYGKTPEQL KKENVSEHLI PHKTFTGNRP SISILLPTLD
GYRIGQLLAI YEHRVAVQGF VWGINSFDQW GVELGKSLAT QVRKQLHASR VKGEPVEGFN
FSTKTLLERY LEATSDVPAD PSTLLPNI