ID   3NB_OXYFU               Reviewed;          74 AA.
AC   C0HJD3;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   11-DEC-2013, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Fulgimotoxin {ECO:0000303|PubMed:23851011};
DE            Short=FTx {ECO:0000303|PubMed:23851011};
OS   Oxybelis fulgidus (Green vine snake) (Coluber fulgidus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Colubridae; Colubrinae; Oxybelis.
OX   NCBI_TaxID=121355;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, MASS
RP   SPECTROMETRY, TOXIC DOSE, DISULFIDE BONDS, AND PYROGLUTAMATE FORMATION AT
RP   GLN-1.
RC   TISSUE=Venom;
RX   PubMed=23851011; DOI=10.1016/j.biochi.2013.06.025;
RA   Heyborne W.H., Mackessy S.P.;
RT   "Identification and characterization of a taxon-specific three-finger toxin
RT   from the venom of the Green Vinesnake (Oxybelis fulgidus; family
RT   Colubridae).";
RL   Biochimie 95:1923-1932(2013).
CC   -!- FUNCTION: Reptile-specific three-finger toxin that is lethal at low
CC       doses for lizards, but not for mice. Probably acts as a neurotoxin.
CC       {ECO:0000269|PubMed:23851011}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:23851011}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23851011}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:23851011}.
CC   -!- PTM: The N-terminus is blocked. {ECO:0000269|PubMed:23851011}.
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000269|PubMed:23851011}.
CC   -!- MASS SPECTROMETRY: Mass=8146.06; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:23851011};
CC   -!- TOXIC DOSE: LD(50) is 0.28 ug/g by intraperitoneal injection in
CC       A.carolinensis and 0.6 ug/g in H.frenatus.
CC       {ECO:0000269|PubMed:23851011}.
CC   -!- MISCELLANEOUS: Not toxic to neonate mice by intraperitoneal injection
CC       at doses up to 5 ug/g. {ECO:0000269|PubMed:23851011}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. Boigatoxin sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; C0HJD3; -.
DR   SMR; C0HJD3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin;
KW   Pyrrolidone carboxylic acid; Secreted; Toxin.
FT   CHAIN           1..74
FT                   /note="Fulgimotoxin"
FT                   /evidence="ECO:0000269|PubMed:23851011"
FT                   /id="PRO_0000424698"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:23851011"
FT   DISULFID        10..34
FT                   /evidence="ECO:0000250|UniProtKB:A0S865"
FT   DISULFID        13..21
FT                   /evidence="ECO:0000250|UniProtKB:A0S865"
FT   DISULFID        27..51
FT                   /evidence="ECO:0000250|UniProtKB:A0S865"
FT   DISULFID        55..66
FT                   /evidence="ECO:0000250|UniProtKB:A0S865"
FT   DISULFID        67..72
FT                   /evidence="ECO:0000250|UniProtKB:A0S865"
SQ   SEQUENCE   74 AA;  8141 MW;  BBA0532B5BA5DA6B CRC64;
     QAIGPPFGLC FQCNQKTSSD CFNAKRCPPF HRTCYTLYKP DGGEEWAVKG CAKGCPTAGP
     DERVKCCHTP RCNN