G6PI_CERS4
ID G6PI_CERS4 Reviewed; 533 AA.
AC Q3J2U4;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_00473};
DE Short=GPI {ECO:0000255|HAMAP-Rule:MF_00473};
DE EC=5.3.1.9 {ECO:0000255|HAMAP-Rule:MF_00473};
DE AltName: Full=Phosphoglucose isomerase {ECO:0000255|HAMAP-Rule:MF_00473};
DE Short=PGI {ECO:0000255|HAMAP-Rule:MF_00473};
DE AltName: Full=Phosphohexose isomerase {ECO:0000255|HAMAP-Rule:MF_00473};
DE Short=PHI {ECO:0000255|HAMAP-Rule:MF_00473};
GN Name=pgi {ECO:0000255|HAMAP-Rule:MF_00473}; OrderedLocusNames=RHOS4_13220;
GN ORFNames=RSP_2736;
OS Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS sphaeroides).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Cereibacter.
OX NCBI_TaxID=272943;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC / NCIMB 8253 / ATH 2.4.1.;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible isomerization of glucose-6-phosphate
CC to fructose-6-phosphate. {ECO:0000255|HAMAP-Rule:MF_00473}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000255|HAMAP-Rule:MF_00473};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_00473}.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000255|HAMAP-Rule:MF_00473}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00473}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000255|HAMAP-
CC Rule:MF_00473}.
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DR EMBL; CP000143; ABA78890.1; -; Genomic_DNA.
DR RefSeq; WP_011337700.1; NZ_CP030271.1.
DR RefSeq; YP_352791.1; NC_007493.2.
DR AlphaFoldDB; Q3J2U4; -.
DR SMR; Q3J2U4; -.
DR STRING; 272943.RSP_2736; -.
DR EnsemblBacteria; ABA78890; ABA78890; RSP_2736.
DR KEGG; rsp:RSP_2736; -.
DR PATRIC; fig|272943.9.peg.1663; -.
DR eggNOG; COG0166; Bacteria.
DR OMA; IGVWYIN; -.
DR PhylomeDB; Q3J2U4; -.
DR UniPathway; UPA00109; UER00181.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000002703; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR Gene3D; 1.10.1390.10; -; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR023096; G6P_Isomerase_C.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; PTHR11469; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase; Reference proteome.
FT CHAIN 1..533
FT /note="Glucose-6-phosphate isomerase"
FT /id="PRO_0000230931"
FT ACT_SITE 341
FT /note="Proton donor"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00473"
FT ACT_SITE 372
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00473"
FT ACT_SITE 501
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00473"
SQ SEQUENCE 533 AA; 58258 MW; 53491B089816B644 CRC64;
MKQIWQALKA HQQAVEHRAI LDLFTDPRRA ETFSTRLGDM LFDWSKTNID HTARDLLIDL
AGAAGVAEKR EAMFSGAKIN ETEGRAVLHT ALRNMDRPVR VDGVDVTPAL RETHARMQAF
VRDLRSGRFT GQGGPITDVV NIGIGGSDLG PAMACLALAP YADGPRCHFV SNVDGAHIHD
TLQDLDPATT LVIVASKTFT TIETMTNAET AKRWMAKRVS DPAAQFAAVS TAADKTAAFG
IDASRVFGFE DWVGGRYSMW GPIGLALMIA IGPEAFDAFL AGGAEMDRHF REAPFAENLP
VLLALVGLWH NQICGHATRA VLPYDQRLAR LPAYLQQLEM ESNGKRVAMD GHELTHHSGP
IVWGEPGTNG QHAFYQLIHQ GSRIVPCEFL VAREGHEPDL AHQHLLLVSN CLAQSEALLR
GRSVEEARAI LGKKGLTGSE LERQARHRVF PGNRPSTVLA YEKLTPATLG RIVALYEHRV
FVEGVILGIN SYDQWGVELG KELALALQPM LEGRAGTEGK DGSTAQLVAY LRR
