G6PI_CHLTA
ID G6PI_CHLTA Reviewed; 524 AA.
AC Q3KLX6;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_00473};
DE Short=GPI {ECO:0000255|HAMAP-Rule:MF_00473};
DE EC=5.3.1.9 {ECO:0000255|HAMAP-Rule:MF_00473};
DE AltName: Full=Phosphoglucose isomerase {ECO:0000255|HAMAP-Rule:MF_00473};
DE Short=PGI {ECO:0000255|HAMAP-Rule:MF_00473};
DE AltName: Full=Phosphohexose isomerase {ECO:0000255|HAMAP-Rule:MF_00473};
DE Short=PHI {ECO:0000255|HAMAP-Rule:MF_00473};
GN Name=pgi {ECO:0000255|HAMAP-Rule:MF_00473}; OrderedLocusNames=CTA_0412;
OS Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=315277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-571B / DSM 19440 / HAR-13;
RX PubMed=16177312; DOI=10.1128/iai.73.10.6407-6418.2005;
RA Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.;
RT "Comparative genomic analysis of Chlamydia trachomatis oculotropic and
RT genitotropic strains.";
RL Infect. Immun. 73:6407-6418(2005).
CC -!- FUNCTION: Catalyzes the reversible isomerization of glucose-6-phosphate
CC to fructose-6-phosphate. {ECO:0000255|HAMAP-Rule:MF_00473}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000255|HAMAP-Rule:MF_00473};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_00473}.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000255|HAMAP-Rule:MF_00473}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00473}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000255|HAMAP-
CC Rule:MF_00473}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX50646.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000051; AAX50646.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q3KLX6; -.
DR SMR; Q3KLX6; -.
DR EnsemblBacteria; AAX50646; AAX50646; CTA_0412.
DR KEGG; cta:CTA_0412; -.
DR HOGENOM; CLU_017947_3_1_0; -.
DR OMA; IGVWYIN; -.
DR UniPathway; UPA00109; UER00181.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000002532; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR Gene3D; 1.10.1390.10; -; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR023096; G6P_Isomerase_C.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; PTHR11469; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase.
FT CHAIN 1..524
FT /note="Glucose-6-phosphate isomerase"
FT /id="PRO_0000230916"
FT ACT_SITE 346
FT /note="Proton donor"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00473"
FT ACT_SITE 377
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00473"
FT ACT_SITE 492
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00473"
SQ SEQUENCE 524 AA; 57649 MW; 4245A7E42A2735C5 CRC64;
MGKGFLDCES LVALQEMALH PIDLTASGCL SEERIQKNSL SAEGFTYSYA TERVDDRCLE
ALQGLTEERE LIKQMECMQQ GAIMNRIEGF QSESRPVLHT ATRAWVRDQD LHEEAAAIAR
HSKEEALRLA EFLYIARAKF STLVQMGIGG SELGPKAMYF AMQGSCPSDK RIFFVSNIDP
DNAAEVLREI DLEQTLVVVV SKSGTTLEPA ANEELFRQAY QNKGLSIAKH FVAVTSQGSP
MDDKSRYLEV FHLWDSIGGR FSATSMVGGV VLGFAFGYEA FIEFLQGAAA IDAHALTPKM
RENLPLLSAM LGVWNRNLLG YPTTAVIPYS TGLKYFTAHL QQCGMESNGK SISREGKEIS
FRTSPIIWGD VGTNCQHSFF QSLHQGTDIV PVEFIGFLHN QRGLDCVLSG SSSSQKLFAN
LVAQSLALAQ GRDNANSNKR FKGNRPSSIL VAQQLSPRIA GSLLAFYEHK FAFQGFCWGI
NSFDQEGVSL GKELATQIIG IMSGNAPVEF PEARGMLRLF NVLT