G6PI_DICDI
ID G6PI_DICDI Reviewed; 561 AA.
AC Q5V9E9; Q54QR6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Glucose-6-phosphate isomerase;
DE Short=GPI;
DE EC=5.3.1.9;
DE AltName: Full=Phosphoglucose isomerase;
DE Short=PGI;
DE AltName: Full=Phosphohexose isomerase;
DE Short=PHI;
GN Name=gpi; Synonyms=g6pi, pgi; ORFNames=DDB_G0283673;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Huang J., Mullapudi N., Lancto C., Scott M., Abrahamsen M., Kissinger J.C.;
RT "Cryptosporidium parvum: phylogenomic evidence for organelle loss,
RT intracellular and horizontal gene transfer.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9;
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000305}.
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DR EMBL; AY581146; AAT92030.1; -; Genomic_DNA.
DR EMBL; AAFI02000056; EAL65603.1; -; Genomic_DNA.
DR RefSeq; XP_638957.1; XM_633865.1.
DR AlphaFoldDB; Q5V9E9; -.
DR SMR; Q5V9E9; -.
DR STRING; 44689.DDB0231026; -.
DR PaxDb; Q5V9E9; -.
DR EnsemblProtists; EAL65603; EAL65603; DDB_G0283673.
DR GeneID; 8624197; -.
DR KEGG; ddi:DDB_G0283673; -.
DR dictyBase; DDB_G0283673; gpi.
DR eggNOG; KOG2446; Eukaryota.
DR HOGENOM; CLU_017947_3_1_1; -.
DR InParanoid; Q5V9E9; -.
DR OMA; VERCKAM; -.
DR PhylomeDB; Q5V9E9; -.
DR Reactome; R-DDI-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-70171; Glycolysis.
DR Reactome; R-DDI-70263; Gluconeogenesis.
DR UniPathway; UPA00109; UER00181.
DR PRO; PR:Q5V9E9; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IBA:GO_Central.
DR GO; GO:0048029; F:monosaccharide binding; IBA:GO_Central.
DR GO; GO:0006094; P:gluconeogenesis; IBA:GO_Central.
DR GO; GO:0051156; P:glucose 6-phosphate metabolic process; IBA:GO_Central.
DR GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR Gene3D; 1.10.1390.10; -; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR023096; G6P_Isomerase_C.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; PTHR11469; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase; Reference proteome.
FT CHAIN 1..561
FT /note="Glucose-6-phosphate isomerase"
FT /id="PRO_0000315252"
FT ACT_SITE 366
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 397
FT /evidence="ECO:0000250"
FT ACT_SITE 525
FT /evidence="ECO:0000250"
SQ SEQUENCE 561 AA; 63465 MW; B49E0503E55D7F77 CRC64;
MEEFKNLKEH YENIGKNINM RKEFESNYGA TRFKDFSKEV NISKQVGTIL LDYSKNRINK
ETMDLLFELA RASKVEEMRN SMFQGEKINI TEDRAVLHTA LRNRDPSAVI KVDGENVIPS
VRKVLDKMRS FSERVRSGQW KGYTGKTITD VVNIGIGGSD LGPVMVTQAL KNYANDKVMR
AHFVSNIDGT HLAETVKHLC PETTLFIVAS KTFTTQETIT NAQSARSWFL EKIGGSSVSA
DVQKHAIGQH FVALSTNEQE VTKFGILKEN MFEFWDWVGG RYSVWSAIGL SVALYVGMDH
FESFLEGAYH MDQHFLNTPL ELNLPVIMGL LGVWYNNFFG CQTQAILPYD QYLSRFPAYF
QQGDMESNGK SVQRNGERVT HSTGPIIWGE PGTNGQHAFY QLIHQGQKII PCDFIASVES
HNPLGKHHQI LLSNFFAQTE ALMKGKNEQE VTNELTKEGL SQEKIKQLLP HKVFEGNRPT
NSIFLHKLTP HSLGALIALY EHKIFVQGII WNINSFDQWG VELGKQLAKS ILPELSDNNE
VSTHDSSTNG LINFYKSNSK L
