G6PI_DROYA
ID G6PI_DROYA Reviewed; 558 AA.
AC P52031; B4P3E0;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Glucose-6-phosphate isomerase;
DE Short=GPI;
DE EC=5.3.1.9;
DE AltName: Full=Phosphoglucose isomerase;
DE Short=PGI;
DE AltName: Full=Phosphohexose isomerase;
DE Short=PHI;
GN Name=Pgi; ORFNames=GE22729;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Brazzaville;
RA McDonald J.H., Kreitman M.E.;
RL Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9;
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000305}.
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DR EMBL; L27673; AAA28787.1; -; Genomic_DNA.
DR EMBL; L27674; AAA28788.1; -; Genomic_DNA.
DR EMBL; L27675; AAB59188.1; -; Genomic_DNA.
DR EMBL; L27676; AAA28806.1; -; Genomic_DNA.
DR EMBL; L27677; AAA28807.1; -; Genomic_DNA.
DR EMBL; L27678; AAA28808.1; -; Genomic_DNA.
DR EMBL; L27679; AAA28809.1; -; Genomic_DNA.
DR EMBL; L27680; AAA28810.1; -; Genomic_DNA.
DR EMBL; L27681; AAA28811.1; -; Genomic_DNA.
DR EMBL; L27682; AAA28812.1; -; Genomic_DNA.
DR EMBL; L27683; AAA28813.1; -; Genomic_DNA.
DR EMBL; L27684; AAA28814.1; -; Genomic_DNA.
DR EMBL; L27685; AAA28815.1; -; Genomic_DNA.
DR EMBL; CM000157; EDW89413.1; -; Genomic_DNA.
DR RefSeq; XP_002089701.1; XM_002089665.2.
DR RefSeq; XP_015054313.1; XM_015198827.1.
DR AlphaFoldDB; P52031; -.
DR SMR; P52031; -.
DR STRING; 7245.FBpp0267739; -.
DR EnsemblMetazoa; FBtr0269247; FBpp0267739; FBgn0013171.
DR EnsemblMetazoa; FBtr0399001; FBpp0358056; FBgn0013171.
DR GeneID; 6528659; -.
DR KEGG; dya:Dyak_GE22729; -.
DR eggNOG; KOG2446; Eukaryota.
DR HOGENOM; CLU_017947_3_1_1; -.
DR OMA; IGVWYIN; -.
DR OrthoDB; 446616at2759; -.
DR PhylomeDB; P52031; -.
DR UniPathway; UPA00109; UER00181.
DR Proteomes; UP000002282; Chromosome 2L.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0042593; P:glucose homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR Gene3D; 1.10.1390.10; -; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR023096; G6P_Isomerase_C.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; PTHR11469; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase.
FT CHAIN 1..558
FT /note="Glucose-6-phosphate isomerase"
FT /id="PRO_0000180545"
FT ACT_SITE 362
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 393
FT /evidence="ECO:0000250"
FT ACT_SITE 523
FT /evidence="ECO:0000250"
SQ SEQUENCE 558 AA; 62191 MW; BB73495CE60D3356 CRC64;
MAGPLPPLNQ EAAFQKLQEY YDSSGKDLNI KDLFVKDAKR FSKYSLRLHT QNDGEILLDY
SKNRINDEVW DLLLALAKVR RVDAARDAMF SGQHINITEN RAVLHTALRN RGTDPVLVDD
KDVMPDVRAE LAHMKEFTNM VISGVWRGCT GKQITDVVNI GIGGSDLGPL MVTEALKPYG
KGLHSHFVSN IDGTHLAEVL KKVNYETTLF IVASKTFTTQ ETITNATSAK TWLLEHSKEP
ESVAKHFVAL STNKEKVTEF GIDSTNMFGF WDWVGGRYSL WSAIGLSICL SIGFENFEQL
LDGAHYMDNH FRTTPLEKNA PVILALLGVW YSNFFKAETH ALLPYDQYLH RFAAYFQQGD
MESNGKFVSK AGKAVKYSTG PIVWGEPGTN GQHAFYQLIH QGTRLIPCDF IAPAQTHNPI
AGGKHHKILL SNFLAQTEAL MAGKTVDEAR AELSKAGLCG NELDNLLPHK VFVGNRPTNS
IVVKKVSPFT LGALIALYEH KIFVQGIIWD INSFDQWGVE LGKQLAKAIE PELDHCNEVS
THDSSTNGLI NFIKANWK
