ID   G6PI_PLAFA              Reviewed;         591 AA.
AC   P18240;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Glucose-6-phosphate isomerase;
DE            Short=GPI;
DE            EC=5.3.1.9;
DE   AltName: Full=Phosphoglucose isomerase;
DE            Short=PGI;
DE   AltName: Full=Phosphohexose isomerase;
DE            Short=PHI;
GN   Name=GGI.R1;
OS   Plasmodium falciparum.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2197273; DOI=10.1016/s0021-9258(19)38351-6;
RA   Kaslow D.C., Hill S.;
RT   "Cloning metabolic pathway genes by complementation in Escherichia coli.
RT   Isolation and expression of Plasmodium falciparum glucose phosphate
RT   isomerase.";
RL   J. Biol. Chem. 265:12337-12341(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC         EC=5.3.1.9;
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 2/4.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the GPI family. {ECO:0000305}.
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DR   EMBL; J05544; AAA29610.1; -; Genomic_DNA.
DR   PIR; A36567; NUZQF.
DR   AlphaFoldDB; P18240; -.
DR   SMR; P18240; -.
DR   PRIDE; P18240; -.
DR   EnsemblProtists; CZU00058; CZU00058; PF3D7_1436000.
DR   VEuPathDB; PlasmoDB:PF3D7_1436000; -.
DR   VEuPathDB; PlasmoDB:Pf7G8-2_000509800; -.
DR   VEuPathDB; PlasmoDB:Pf7G8_140041200; -.
DR   VEuPathDB; PlasmoDB:PfCD01_140041400; -.
DR   VEuPathDB; PlasmoDB:PfDd2_140040400; -.
DR   VEuPathDB; PlasmoDB:PfGA01_140041500; -.
DR   VEuPathDB; PlasmoDB:PfGB4_140042100; -.
DR   VEuPathDB; PlasmoDB:PfGN01_140041300; -.
DR   VEuPathDB; PlasmoDB:PfHB3_140041700; -.
DR   VEuPathDB; PlasmoDB:PfIT_140042400; -.
DR   VEuPathDB; PlasmoDB:PfKE01_140040900; -.
DR   VEuPathDB; PlasmoDB:PfKH01_140041500; -.
DR   VEuPathDB; PlasmoDB:PfKH02_140041700; -.
DR   VEuPathDB; PlasmoDB:PfML01_140041400; -.
DR   VEuPathDB; PlasmoDB:PfNF135_140040200; -.
DR   VEuPathDB; PlasmoDB:PfNF166_140038900; -.
DR   VEuPathDB; PlasmoDB:PfNF54_140039800; -.
DR   VEuPathDB; PlasmoDB:PfSD01_140039300; -.
DR   VEuPathDB; PlasmoDB:PfSN01_140043200; -.
DR   VEuPathDB; PlasmoDB:PfTG01_140041300; -.
DR   SABIO-RK; P18240; -.
DR   UniPathway; UPA00109; UER00181.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05015; SIS_PGI_1; 1.
DR   CDD; cd05016; SIS_PGI_2; 1.
DR   Gene3D; 1.10.1390.10; -; 1.
DR   HAMAP; MF_00473; G6P_isomerase; 1.
DR   InterPro; IPR001672; G6P_Isomerase.
DR   InterPro; IPR023096; G6P_Isomerase_C.
DR   InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR035476; SIS_PGI_1.
DR   InterPro; IPR035482; SIS_PGI_2.
DR   PANTHER; PTHR11469; PTHR11469; 1.
DR   Pfam; PF00342; PGI; 1.
DR   PRINTS; PR00662; G6PISOMERASE.
DR   SUPFAM; SSF53697; SSF53697; 1.
DR   PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR   PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR   PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase.
FT   CHAIN           1..591
FT                   /note="Glucose-6-phosphate isomerase"
FT                   /id="PRO_0000180547"
FT   ACT_SITE        380
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        411
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        540
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   591 AA;  68766 MW;  82EC175BD2835B21 CRC64;
     MNMEITNLKS YKELVTLSAE EKTKDLKDYL NDKNRSESLI KKFKNFYMDL SRQRYSEKTL
     NKLVEYAEEV ELKKKVEKTF MGEKVNMTEN RSVLHTALRI PIEKINTHKI IIDNKNVLED
     VHGVLKKIEK YSDDIRNGVI KTCKNTKFKN VICIGIGGSY LGTEFVYEAM KYYYYNMELN
     KNEKDQVNNF NNNYDQDNVF NVRFLANVDP NDVNRAIQNL DQYDTLVIII SKTFTTAETM
     LNARSIKKWL SLKIKDDENL SKHMVAVSTN LKLTDEFGIS RDNVFEFWDW VGGRFSVTSS
     VGILPLSIAF GYKNMRNFLN GCHDMDEHFL HADLKENIPV LLALTSFYNS HFFDYKNVAI
     LPYFQNLLKF SAHIQQLSME SNGKSVDRNN QPIHYNTCQV YFGEPGTNGQ HSFYQLIHQG
     QVIPVELIGF KHSHFPIKFD KEVVSNHDEL MTNFFAQADA LAIGKTYEQV KEENEKNKMS
     PELLTHKVFN GNRPSTLLLF DELNFYTCGL LLSLYESRIV AEGFLLNINS FDQWGVELGK
     VLAKEVRNYF NDTRNQKKSD NTYNFNESTK NFIKLLLVQI KKKKKINTNL K