G6PT2_HUMAN
ID G6PT2_HUMAN Reviewed; 533 AA.
AC P57057; D3DSJ7; Q9HAQ1;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Glucose-6-phosphate exchanger SLC37A1 {ECO:0000305|PubMed:21949678};
DE AltName: Full=Glycerol-3-phosphate permease {ECO:0000303|PubMed:11112347};
DE Short=G-3-P permease {ECO:0000303|PubMed:11112347};
DE AltName: Full=Solute carrier family 37 member 1 {ECO:0000312|HGNC:HGNC:11024};
GN Name=SLC37A1 {ECO:0000312|HGNC:HGNC:11024};
GN Synonyms=G3PP {ECO:0000303|PubMed:11112347};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-247, AND TISSUE SPECIFICITY.
RX PubMed=11112347; DOI=10.1006/geno.2000.6395;
RA Bartoloni L., Wattenhofer M., Kudoh J., Berry A., Shibuya K., Kawasaki K.,
RA Wang J., Asakawa S., Talior I., Bonne-Tamir B., Rossier C., Michaud J.,
RA McCabe E.R.B., Minoshima S., Shimizu N., Scott H.S., Antonarakis S.E.;
RT "Cloning and characterization of a putative human glycerol 3-phosphate
RT permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two
RT candidate phenotypes, DFNB10 and a glycerol kinase deficiency.";
RL Genomics 70:190-200(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ILE-414.
RA Solans A., Estivill X., de la Luna S.;
RT "Cloning and characterization of human glycerol 3-phosphate permease gene
RT (SLC37A1).";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, ACTIVITY REGULATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=21949678; DOI=10.1371/journal.pone.0023157;
RA Pan C.J., Chen S.Y., Jun H.S., Lin S.R., Mansfield B.C., Chou J.Y.;
RT "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate
RT antiporters.";
RL PLoS ONE 6:E23157-E23157(2011).
CC -!- FUNCTION: Inorganic phosphate and glucose-6-phosphate antiporter. May
CC transport cytoplasmic glucose-6-phosphate into the lumen of the
CC endoplasmic reticulum and translocate inorganic phosphate into the
CC opposite direction. Independent of a lumenal glucose-6-phosphatase. May
CC not play a role in homeostatic regulation of blood glucose levels.
CC {ECO:0000269|PubMed:21949678}.
CC -!- ACTIVITY REGULATION: Inhibited by vanadate but not by chlorogenic acid.
CC {ECO:0000269|PubMed:21949678}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:21949678}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in numerous tissues, with highest
CC expression in pancreas, kidney, bone marrow, spleen, liver, small
CC intestine, as well as in fetal brain, liver and spleen.
CC {ECO:0000269|PubMed:11112347, ECO:0000269|PubMed:21949678}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR EMBL; AJ269529; CAB87248.1; -; mRNA.
DR EMBL; AJ277912; CAB91985.1; -; mRNA.
DR EMBL; AJ277913; CAB91986.1; -; mRNA.
DR EMBL; AF311320; AAG29853.1; -; mRNA.
DR EMBL; AP001625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471079; EAX09552.1; -; Genomic_DNA.
DR EMBL; CH471079; EAX09553.1; -; Genomic_DNA.
DR CCDS; CCDS13689.1; -.
DR RefSeq; NP_001307466.1; NM_001320537.1.
DR RefSeq; NP_061837.3; NM_018964.3.
DR RefSeq; XP_016883866.1; XM_017028377.1.
DR RefSeq; XP_016883867.1; XM_017028378.1.
DR RefSeq; XP_016883868.1; XM_017028379.1.
DR RefSeq; XP_016883869.1; XM_017028380.1.
DR AlphaFoldDB; P57057; -.
DR BioGRID; 119832; 6.
DR IntAct; P57057; 4.
DR MINT; P57057; -.
DR STRING; 9606.ENSP00000344648; -.
DR TCDB; 2.A.1.4.7; the major facilitator superfamily (mfs).
DR GlyGen; P57057; 2 sites.
DR iPTMnet; P57057; -.
DR PhosphoSitePlus; P57057; -.
DR BioMuta; SLC37A1; -.
DR DMDM; 317373359; -.
DR EPD; P57057; -.
DR MassIVE; P57057; -.
DR MaxQB; P57057; -.
DR PaxDb; P57057; -.
DR PeptideAtlas; P57057; -.
DR PRIDE; P57057; -.
DR ProteomicsDB; 56976; -.
DR Antibodypedia; 23842; 82 antibodies from 18 providers.
DR DNASU; 54020; -.
DR Ensembl; ENST00000352133.3; ENSP00000344648.2; ENSG00000160190.14.
DR Ensembl; ENST00000398341.7; ENSP00000381383.3; ENSG00000160190.14.
DR GeneID; 54020; -.
DR KEGG; hsa:54020; -.
DR MANE-Select; ENST00000352133.3; ENSP00000344648.2; NM_001320537.2; NP_001307466.1.
DR UCSC; uc002zbi.3; human.
DR CTD; 54020; -.
DR DisGeNET; 54020; -.
DR GeneCards; SLC37A1; -.
DR HGNC; HGNC:11024; SLC37A1.
DR HPA; ENSG00000160190; Tissue enhanced (intestine).
DR MIM; 608094; gene.
DR neXtProt; NX_P57057; -.
DR OpenTargets; ENSG00000160190; -.
DR PharmGKB; PA35892; -.
DR VEuPathDB; HostDB:ENSG00000160190; -.
DR eggNOG; KOG2533; Eukaryota.
DR GeneTree; ENSGT00940000159245; -.
DR HOGENOM; CLU_001265_31_6_1; -.
DR InParanoid; P57057; -.
DR OMA; WEPFDKS; -.
DR OrthoDB; 964162at2759; -.
DR PhylomeDB; P57057; -.
DR TreeFam; TF314991; -.
DR PathwayCommons; P57057; -.
DR Reactome; R-HSA-70263; Gluconeogenesis.
DR SignaLink; P57057; -.
DR BioGRID-ORCS; 54020; 9 hits in 1074 CRISPR screens.
DR ChiTaRS; SLC37A1; human.
DR GenomeRNAi; 54020; -.
DR Pharos; P57057; Tbio.
DR PRO; PR:P57057; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P57057; protein.
DR Bgee; ENSG00000160190; Expressed in olfactory segment of nasal mucosa and 121 other tissues.
DR ExpressionAtlas; P57057; baseline and differential.
DR Genevisible; P57057; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; IDA:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0015760; P:glucose-6-phosphate transport; IDA:UniProtKB.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IDA:UniProtKB.
DR CDD; cd17344; MFS_SLC37A1_2; 1.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR044740; SLC37A1_2.
DR InterPro; IPR000849; Sugar_P_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Antiport; Endoplasmic reticulum; Glycoprotein; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..533
FT /note="Glucose-6-phosphate exchanger SLC37A1"
FT /id="PRO_0000199890"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 263
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 247
FT /note="D -> N (in dbSNP:rs768541152)"
FT /evidence="ECO:0000269|PubMed:11112347"
FT /id="VAR_017110"
FT VARIANT 414
FT /note="V -> I (in dbSNP:rs228104)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_017111"
FT CONFLICT 223
FT /note="F -> L (in Ref. 2; AAG29853)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="H -> Q (in Ref. 2; AAG29853)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 533 AA; 57648 MW; FA978FE2943C80AA CRC64;
MARLPAGIRF IISFSRDQWY RAFIFILTFL LYASFHLSRK PISIVKGELH KYCTAWDEAD
VRFSSQNRKS GSAAPHQLPD NETDCGWAPF DKNNYQQLLG ALDYSFLCAY AVGMYLSGII
GERLPIRYYL TFGMLASGAF TALFGLGYFY NIHSFGFYVV TQVINGLVQT TGWPSVVTCL
GNWFGKGRRG LIMGVWNSHT SVGNILGSLI AGYWVSTCWG LSFVVPGAIV AAMGIVCFLF
LIEHPNDVRC SSTLVTHSKG YENGTNRLRL QKQILKSEKN KPLDPEMQCL LLSDGKGSIH
PNHVVILPGD GGSGTAAISF TGALKIPGVI EFSLCLLFAK LVSYTFLFWL PLYITNVDHL
DAKKAGELST LFDVGGIFGG ILAGVISDRL EKRASTCGLM LLLAAPTLYI FSTVSKMGLE
ATIAMLLLSG ALVSGPYTLI TTAVSADLGT HKSLKGNAHA LSTVTAIIDG TGSVGAALGP
LLAGLLSPSG WSNVFYMLMF ADACALLFLI RLIHKELSCP GSATGDQVPF KEQ
