G6PT2_MOUSE
ID G6PT2_MOUSE Reviewed; 531 AA.
AC Q8R070; Q3UPC2;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Glucose-6-phosphate exchanger SLC37A1 {ECO:0000305};
DE AltName: Full=Solute carrier family 37 member 1 {ECO:0000312|MGI:MGI:2446181};
GN Name=Slc37a1 {ECO:0000312|MGI:MGI:2446181};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inorganic phosphate and glucose-6-phosphate antiporter. May
CC transport cytoplasmic glucose-6-phosphate into the lumen of the
CC endoplasmic reticulum and translocate inorganic phosphate into the
CC opposite direction. Independent of a lumenal glucose-6-phosphatase. May
CC not play a role in homeostatic regulation of blood glucose levels.
CC {ECO:0000250|UniProtKB:P57057}.
CC -!- ACTIVITY REGULATION: Inhibited by vanadate but not by chlorogenic acid.
CC {ECO:0000250|UniProtKB:P57057}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P57057}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK033656; BAC28411.1; -; mRNA.
DR EMBL; AK143636; BAE25474.1; -; mRNA.
DR EMBL; AK153706; BAE32150.1; -; mRNA.
DR EMBL; AC154652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466640; EDL40361.1; -; Genomic_DNA.
DR EMBL; CH466640; EDL40362.1; -; Genomic_DNA.
DR EMBL; BC027294; AAH27294.1; -; mRNA.
DR CCDS; CCDS37548.1; -.
DR RefSeq; NP_001229356.1; NM_001242427.1.
DR RefSeq; NP_694702.1; NM_153062.2.
DR RefSeq; XP_006524160.1; XM_006524097.3.
DR RefSeq; XP_011244698.1; XM_011246396.2.
DR AlphaFoldDB; Q8R070; -.
DR STRING; 10090.ENSMUSP00000128223; -.
DR PhosphoSitePlus; Q8R070; -.
DR MaxQB; Q8R070; -.
DR PaxDb; Q8R070; -.
DR PRIDE; Q8R070; -.
DR ProteomicsDB; 265723; -.
DR Antibodypedia; 23842; 82 antibodies from 18 providers.
DR DNASU; 224674; -.
DR Ensembl; ENSMUST00000165149; ENSMUSP00000128223; ENSMUSG00000024036.
DR Ensembl; ENSMUST00000171233; ENSMUSP00000126111; ENSMUSG00000024036.
DR GeneID; 224674; -.
DR KEGG; mmu:224674; -.
DR UCSC; uc008buw.1; mouse.
DR CTD; 54020; -.
DR MGI; MGI:2446181; Slc37a1.
DR VEuPathDB; HostDB:ENSMUSG00000024036; -.
DR eggNOG; KOG2533; Eukaryota.
DR GeneTree; ENSGT00940000159245; -.
DR HOGENOM; CLU_001265_31_6_1; -.
DR InParanoid; Q8R070; -.
DR OMA; WEPFDKS; -.
DR OrthoDB; 964162at2759; -.
DR PhylomeDB; Q8R070; -.
DR TreeFam; TF314991; -.
DR Reactome; R-MMU-70263; Gluconeogenesis.
DR BioGRID-ORCS; 224674; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Slc37a2; mouse.
DR PRO; PR:Q8R070; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8R070; protein.
DR Bgee; ENSMUSG00000024036; Expressed in colon and 120 other tissues.
DR ExpressionAtlas; Q8R070; baseline and differential.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0015760; P:glucose-6-phosphate transport; ISS:UniProtKB.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; ISS:UniProtKB.
DR CDD; cd17344; MFS_SLC37A1_2; 1.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR044740; SLC37A1_2.
DR InterPro; IPR000849; Sugar_P_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Antiport; Endoplasmic reticulum; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..531
FT /note="Glucose-6-phosphate exchanger SLC37A1"
FT /id="PRO_0000436067"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 53..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 313
FT /note="M -> T (in Ref. 1; BAE25474)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 531 AA; 57355 MW; FEE04BFC2EFA779D CRC64;
MALLPVGIRF IISFSRDQWY RAFIFMLTFL LYASFHLSRK PISIVKGELH KQCTAGDGPE
SPFSDPSSST RHGPTHWLLN NETDCGWAPF DKNNYQQLLG ALDYAFLCAY AIGMYLSGII
GERLPIRYYL TFGMLASGAF TALFGLGYFY NIHSLGFYVV TQIINGLVQT TGWPSVVTCL
SNWFGKGRRG LIMGIWNSHT SVGNILGSLI AGYWVSTCWG LSFIVPGAIV AAMGIVCFLF
LIEHPKDVKC SSTLPTHPRA SENGINRFRL QKQTTYSEKN GPLDPELQCL LLSDGKNPLH
PSHIVVLPAD GNMAAISFTG ALRIPGVIEF SLCLLFAKLV SYTFLFWLPL YITSVDHLDA
KKAGELSTLF DVGGIFGGIL AGVISDRLEK RASTCGLMLL LAAPTLYVFS SVSRMGLEAT
IAMLLLSGAL VSGPYALITT AVSADLGTHK SLKGNSHALS TVTAIIDGTG SVGAALGPLL
AGLISPSGWS NVFYMLMFAD ACALLFLVRL IHKELSCPGP AAGIQAPLKE H
