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G6PT3_DANRE
ID   G6PT3_DANRE             Reviewed;         494 AA.
AC   Q7SY29; Q4V952;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Glucose-6-phosphate exchanger SLC37A2 {ECO:0000305};
DE   AltName: Full=Solute carrier family 37 member 2 {ECO:0000250|UniProtKB:Q8TED4};
GN   Name=slc37a2 {ECO:0000250|UniProtKB:Q8TED4};
GN   ORFNames=zgc:63583 {ECO:0000312|EMBL:AAH55147.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inorganic phosphate and glucose-6-phosphate antiporter. May
CC       transport cytoplasmic glucose-6-phosphate into the lumen of the
CC       endoplasmic reticulum and translocate inorganic phosphate into the
CC       opposite direction. {ECO:0000250|UniProtKB:Q8TED4}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8TED4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7SY29-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7SY29-2; Sequence=VSP_028965;
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR   EMBL; BC055147; AAH55147.1; -; mRNA.
DR   EMBL; BC097056; AAH97056.1; -; mRNA.
DR   RefSeq; NP_998179.1; NM_213014.1.
DR   AlphaFoldDB; Q7SY29; -.
DR   SMR; Q7SY29; -.
DR   STRING; 7955.ENSDARP00000038646; -.
DR   PaxDb; Q7SY29; -.
DR   GeneID; 406287; -.
DR   KEGG; dre:406287; -.
DR   CTD; 219855; -.
DR   ZFIN; ZDB-GENE-040426-1949; slc37a2.
DR   eggNOG; KOG2533; Eukaryota.
DR   InParanoid; Q7SY29; -.
DR   PhylomeDB; Q7SY29; -.
DR   Reactome; R-DRE-70263; Gluconeogenesis.
DR   PRO; PR:Q7SY29; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; ISS:UniProtKB.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0015760; P:glucose-6-phosphate transport; ISS:UniProtKB.
DR   GO; GO:0090382; P:phagosome maturation; IMP:ZFIN.
DR   GO; GO:0035435; P:phosphate ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd17344; MFS_SLC37A1_2; 1.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR044740; SLC37A1_2.
DR   InterPro; IPR000849; Sugar_P_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Antiport; Endoplasmic reticulum; Glycoprotein;
KW   Membrane; Reference proteome; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..494
FT                   /note="Glucose-6-phosphate exchanger SLC37A2"
FT                   /id="PRO_0000308324"
FT   TRANSMEM        20..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        63
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         491..494
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028965"
FT   CONFLICT        381
FT                   /note="P -> L (in Ref. 1; AAH97056)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        414
FT                   /note="C -> S (in Ref. 1; AAH97056)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   494 AA;  54040 MW;  F583EBEC623864EB CRC64;
     MKSLAPGIKL ITSFSRDSWY RFSILFLTFV FYTSYHLSRK PISIVKSQLH RNCSNVVHPA
     NLNITDNDTW CDWVPFDGKN YQNLFGVLDN CFLVAYAVGM FFSGIFGERL PLRYYLSTGM
     LLSGLFTALF GLGFYWQIHS LWYYCLVQAL NGLVQTTGWP AVVACVGNWF GKGKRGFIMG
     VWNSHTSVGN ILGSLIAGVY VSSAWGLSFI VPGIIIASTG VICFLFLVER PEDVNCTAPQ
     HHERVEEEPL LRNSSTNEEI FNSHTSTAVE PVEDHSEAIS FCGALRIPGV VEFSLCLLFA
     KLVSYTFLYW LPLYIANVAH FDPKKAGDLS TLFDVGGILG GIVAGLVSDY TGGRASTCCA
     MLIIAAPMLF LYNKIGQNGL PTTVGMLLWC GALVNGPYAL ITTAVSADLG THECLRGNSR
     ALSTVTAIID GTGSIGAAVG PLLAGLISPT GWNNVFYMLI AADVLACLLL SRLVYKEIRG
     WCGYTTRQRG FKEI
 
 
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