ID   G6PT3_XENLA             Reviewed;         499 AA.
AC   Q8AVC3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Glucose-6-phosphate exchanger SLC37A2 {ECO:0000305};
DE   AltName: Full=Solute carrier family 37 member 2 {ECO:0000250|UniProtKB:Q8TED4};
GN   Name=slc37a2 {ECO:0000250|UniProtKB:Q8TED4};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inorganic phosphate and glucose-6-phosphate antiporter. May
CC       transport cytoplasmic glucose-6-phosphate into the lumen of the
CC       endoplasmic reticulum and translocate inorganic phosphate into the
CC       opposite direction. {ECO:0000250|UniProtKB:Q8TED4}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8TED4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR   EMBL; BC042235; AAH42235.1; -; mRNA.
DR   RefSeq; NP_001079430.1; NM_001085961.1.
DR   AlphaFoldDB; Q8AVC3; -.
DR   SMR; Q8AVC3; -.
DR   DNASU; 379117; -.
DR   GeneID; 379117; -.
DR   KEGG; xla:379117; -.
DR   CTD; 379117; -.
DR   Xenbase; XB-GENE-990254; slc37a2.L.
DR   OMA; AMPYLID; -.
DR   OrthoDB; 964162at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 379117; Expressed in blastula and 19 other tissues.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; ISS:UniProtKB.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0015760; P:glucose-6-phosphate transport; ISS:UniProtKB.
DR   GO; GO:0035435; P:phosphate ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd17344; MFS_SLC37A1_2; 1.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR044740; SLC37A1_2.
DR   InterPro; IPR000849; Sugar_P_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Antiport; Endoplasmic reticulum; Glycoprotein; Membrane;
KW   Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..499
FT                   /note="Glucose-6-phosphate exchanger SLC37A2"
FT                   /id="PRO_0000308325"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  54409 MW;  59DC45ECE01D9211 CRC64;
     MRSSLAPAIR LMQSVSRDSC YRGFIIVMTF LFYTCYHLSR KPISIVKGQL HRNCSALPNP
     PNISENDTTW CSWAPFENTN YKELLGSLDT AFLVSYAIGM FFSGIFGERL PLRYYLSGGM
     IISGIFTSFM GFGYYWNIHA LWYYILFQIL NGLAQTTGWP AVVTCMGNWF GKGKRGFIMG
     IWNSHTAVGN ILGSLIAGAF VSTAWGLSFI VPGIIIAAFG IFCFFFLVEY PEDVGCTPPQ
     QPEEAKHDLE NIPVSYNSTD TIFKSTESNA DDSENAHTEV EHPQAISFIG ALRIPGVVEF
     SLCLLFAKLV SYTFLYWLPL YIANDAQFDP KAAGDLSTLF DVGGIIGGIL AGGISDYTGK
     SAITCTIMLI LTAPMLFIYN YFGQTGISTT IAMLIICGIL VNGPYSLITT AVSADLGTHE
     SLQGNAKALS TVTAIIDGSG SIGAALGPSL AGVLSSRGWN YVFYMLIAAD ICACLLLARL
     VYKEIRSLCG GERKSYTEM