ID   G6PT3_XENTR             Reviewed;         499 AA.
AC   Q5M7K3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Glucose-6-phosphate exchanger SLC37A2 {ECO:0000305};
DE   AltName: Full=Solute carrier family 37 member 2 {ECO:0000250|UniProtKB:Q8TED4};
GN   Name=slc37a2 {ECO:0000250|UniProtKB:Q8TED4};
GN   ORFNames=TEgg043o11.1 {ECO:0000312|EMBL:CAJ83734.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inorganic phosphate and glucose-6-phosphate antiporter. May
CC       transport cytoplasmic glucose-6-phosphate into the lumen of the
CC       endoplasmic reticulum and translocate inorganic phosphate into the
CC       opposite direction. {ECO:0000250|UniProtKB:Q8TED4}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8TED4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR   EMBL; CR762105; CAJ83734.1; -; mRNA.
DR   EMBL; BC088593; AAH88593.1; -; mRNA.
DR   RefSeq; NP_001011395.1; NM_001011395.1.
DR   AlphaFoldDB; Q5M7K3; -.
DR   SMR; Q5M7K3; -.
DR   PRIDE; Q5M7K3; -.
DR   Ensembl; ENSXETT00000094617; ENSXETP00000069937; ENSXETG00000003934.
DR   GeneID; 496867; -.
DR   KEGG; xtr:496867; -.
DR   CTD; 219855; -.
DR   Xenbase; XB-GENE-990247; slc37a2.
DR   InParanoid; Q5M7K3; -.
DR   OrthoDB; 964162at2759; -.
DR   Reactome; R-XTR-70263; Gluconeogenesis.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003934; Expressed in egg cell and 13 other tissues.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; ISS:UniProtKB.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0015760; P:glucose-6-phosphate transport; ISS:UniProtKB.
DR   GO; GO:0035435; P:phosphate ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd17344; MFS_SLC37A1_2; 1.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR044740; SLC37A1_2.
DR   InterPro; IPR000849; Sugar_P_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Antiport; Endoplasmic reticulum; Glycoprotein; Membrane;
KW   Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..499
FT                   /note="Glucose-6-phosphate exchanger SLC37A2"
FT                   /id="PRO_0000308326"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  54298 MW;  51904DD290D3F2D3 CRC64;
     MRSSLAPAIR LMQSVSRDSC YRGFIIVMTF LFYTCYHMSR KPISIVKGQL HRNCSALPSP
     PNISANDTTW CSWAPFENSN YKELLGSLDT AFLVSYAIGM FFSGIFGERL PLRYYLSGGM
     IICGIFTSFM GLGYYWNIHA LWYYILFQIL NGLAQTTGWP SVVTCMGNWF GKGKRGFIMG
     IWNSHTAVGN ILGSLIAGAF VSTAWGLSFI VPGIIIAAFG IFCFFFLVEY PEDVGCTPPQ
     QPEDTKENLE DMPVSYNSTD TICKSTESNE DDSGNAHTET EHPQAISFFG ALRIPGVVEF
     SLCLLFAKLV SYTFLYWLPL YIANDAQFDP KAAGDLSTLF DVGGIIGGIL AGGISDYTGK
     SAITCTIMLI LTAPMLFIYN YLGQTGVSTT VAMLIVCGIL VNGPYSLITT AVSADLGTHE
     SLQGNAKALS TVTAIIDGSG SIGAALGPSL AGVLSSRGWN YVFYMLIAAD ICACLLLVRL
     VYKEIRTLCG GMRKSYTEM