ID   G7_VAR67                Reviewed;         371 AA.
AC   P0DSU1; P32997;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 7.
DE   RecName: Full=Assembly protein G7;
GN   ORFNames=G7L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383392; DOI=10.1016/0168-1702(93)90110-9;
RA   Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S.,
RA   Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V.,
RA   Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G.,
RA   Sandakhchiev L.S.;
RT   "Nucleotide sequence analysis of variola virus HindIII M, L, I genome
RT   fragments.";
RL   Virus Res. 27:25-35(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Late protein which is a part of a large complex required for
CC       early virion morphogenesis. This complex participates in the formation
CC       of virosomes and the incorporation of virosomal contents into nascent
CC       immature virions (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex composed of A30, G7, F10 kinase, A15, D2,
CC       D3, and J1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Virion
CC       {ECO:0000250}. Note=Localizes in cytoplasmic virus factories and
CC       present in the virion core. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Phosphorylated on serines by F10 kinase, phosphorylation state is
CC       regulated by H1 phosphatase. {ECO:0000250}.
CC   -!- PTM: Undergoes proteolytic processing during morphogenesis, probably
CC       required for the transformation of immature virions (IV) into mature
CC       virions (MV). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae G7 family. {ECO:0000305}.
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DR   EMBL; X67119; CAA47569.1; -; Genomic_DNA.
DR   EMBL; X69198; CAA49011.1; -; Genomic_DNA.
DR   PIR; S33084; S33084.
DR   RefSeq; NP_042114.1; NC_001611.1.
DR   GeneID; 1486436; -.
DR   KEGG; vg:1486436; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008787; Poxvirus_G7.
DR   Pfam; PF05503; Pox_G7; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Phosphoprotein; Reference proteome; Virion.
FT   CHAIN           1..371
FT                   /note="Assembly protein G7"
FT                   /id="PRO_0000099539"
FT   SITE            187..188
FT                   /note="Cleavage; by I7 protease"
FT                   /evidence="ECO:0000250"
FT   SITE            238..239
FT                   /note="Cleavage; by I7 protease"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   371 AA;  41922 MW;  9D14A208A9083DB3 CRC64;
     MAAEQRRSTI FDIVSKCIVQ SVLRDISINS EYIESKAKQL CYCPASKKES VINGIYNCCE
     SNIEIMDKEQ LLKILDNLRC HSAHVCNATD FWRLYNSLKR FTHTTAFFNT CKPTILATLN
     TLITLILSNK LLYAAEMVEY LENQLDSSNK SMSQELAELL EMKYALINLV QYRILPMIIG
     EPIIVAGFSG KEPISNYSAE VERLMELPVK TDIVNTTYDF LARKGIDTSN NIAEYIAGLK
     IEEIEKVEKY LPEVISTIAN SNIIKNKKSI FPANINDKQI MECSKMLDTS EKYSKGYKTD
     GAVTSPLTGN NTITTFIPIS ASDMQKFTIL EYLYIMRVMA NNVKKKNEGK NNGGVVMHIN
     SPFKVINLPK C