G9_VARV
ID G9_VARV Reviewed; 340 AA.
AC P0DOS8; P32998; Q76Q19;
DT 16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2019, sequence version 1.
DT 25-MAY-2022, entry version 11.
DE RecName: Full=Myristoylated protein G9;
GN ORFNames=G9R, H9R, I10R;
OS Variola virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10255;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bangladesh-1975;
RX PubMed=8264798; DOI=10.1038/366748a0;
RA Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT "Potential virulence determinants in terminal regions of variola smallpox
RT virus genome.";
RL Nature 366:748-751(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Garcia-1966;
RA Shchelkunov S.N., Sosnovtsev S.V., Totmenin A.V., Resenchuk S.M.,
RA Blinov V.M., Sandakhchiev L.S.;
RL Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Garcia-1966;
RX PubMed=10639322; DOI=10.1006/viro.1999.0086;
RA Shchelkunov S.N., Totmenin A.V., Loparev V.N., Safronov P.F., Gutorov V.V.,
RA Chizhikov V.E., Knight J.C., Parsons J.M., Massung R.F., Esposito J.J.;
RT "Alastrim smallpox variola minor virus genome DNA sequences.";
RL Virology 266:361-386(2000).
CC -!- FUNCTION: Envelope protein part of the entry-fusion complex responsible
CC for the virus membrane fusion with host cell membrane during virus
CC entry. Also plays a role in cell-cell fusion (syncytium formation) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of a stable entry-fusion complex (EFC) which is at least
CC composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation
CC of the viral membrane is necessary for the assembly of the complex.
CC Interacts with A16; this heterodimer further interact with A56/K2
CC fusion regulatory heterodimer (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC II membrane protein {ECO:0000305}. Note=Component of the mature virion
CC (MV) membrane. The mature virion is located in the cytoplasm of
CC infected cells and is probably released by cell lysis (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the poxviridae A16/G9/J5 family. {ECO:0000305}.
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DR EMBL; L22579; AAA60820.1; -; Genomic_DNA.
DR EMBL; X76267; CAA53877.1; -; Genomic_DNA.
DR EMBL; Y16780; CAB54672.1; -; Genomic_DNA.
DR PIR; F72159; F72159.
DR PIR; T28510; T28510.
DR RefSeq; NP_042116.1; NC_001611.1.
DR GeneID; 1486438; -.
DR KEGG; vg:1486438; -.
DR Proteomes; UP000111493; Genome.
DR Proteomes; UP000119805; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR InterPro; IPR004251; Pox_virus_G9/A16.
DR Pfam; PF03003; Pox_G9-A16; 1.
PE 3: Inferred from homology;
KW Fusion of virus membrane with host cell membrane;
KW Fusion of virus membrane with host membrane; Lipoprotein; Membrane;
KW Myristate; Signal-anchor; Transmembrane; Transmembrane helix;
KW Viral envelope protein; Viral penetration into host cytoplasm; Virion;
KW Virus entry into host cell.
FT INIT_MET 1
FT /note="Removed; by host"
FT /evidence="ECO:0000250"
FT CHAIN 2..340
FT /note="Myristoylated protein G9"
FT /id="PRO_0000448196"
FT TOPO_DOM 2..319
FT /note="Virion surface"
FT TRANSMEM 320..340
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine; by host"
FT /evidence="ECO:0000250"
SQ SEQUENCE 340 AA; 38766 MW; 1217D665801A2343 CRC64;
MGGGVSVELP KRDPPPGVPT DEMLLNVDKM HDVIAPAKLL EYVHIGPLAK DKEDKVKKRY
PEFRLVNTGP GGLSALLRQS YNGTAPNCCH TFNRTHYWKK DGKISDKYEE GAVLESCWPD
VHDTGKCDVN LFDWCQGDTF DRNICHQWIG SAFNRSDRTV EGQQSLINLY NKMQTLCSKD
ASVPICESFL HHLRAHNTED SKEMIDYILR QQSANFKQKY MRCSYPTRDK LEESLKYAEP
RECWDPECSN ANVNFLLTRN YNNLGLCNIV RCNTSVNNLQ MDKTSSLRLS CGLSNSDRFS
TVPVNRAKVV QHNIKHSFDL KLHLISLLSL LVIWILIVAI