ID   GA45A_BOVIN             Reviewed;         165 AA.
AC   Q3ZBN6;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Growth arrest and DNA damage-inducible protein GADD45 alpha;
GN   Name=GADD45A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Pancreas;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Might affect PCNA interaction with some CDK (cell division
CC       protein kinase) complexes; stimulates DNA excision repair in vitro and
CC       inhibits entry of cells into S phase. In T-cells, functions as a
CC       regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with AURKA, PCNA, GADD45GIP1 and MAPK14.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GADD45 family. {ECO:0000305}.
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DR   EMBL; BC103198; AAI03199.1; -; mRNA.
DR   RefSeq; NP_001029419.1; NM_001034247.1.
DR   AlphaFoldDB; Q3ZBN6; -.
DR   BMRB; Q3ZBN6; -.
DR   SMR; Q3ZBN6; -.
DR   STRING; 9913.ENSBTAP00000033363; -.
DR   PaxDb; Q3ZBN6; -.
DR   PRIDE; Q3ZBN6; -.
DR   Ensembl; ENSBTAT00000033450; ENSBTAP00000033363; ENSBTAG00000013860.
DR   GeneID; 505463; -.
DR   KEGG; bta:505463; -.
DR   CTD; 1647; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013860; -.
DR   VGNC; VGNC:29206; GADD45A.
DR   eggNOG; ENOG502RY8P; Eukaryota.
DR   GeneTree; ENSGT00950000182964; -.
DR   HOGENOM; CLU_118164_0_0_1; -.
DR   InParanoid; Q3ZBN6; -.
DR   OMA; CLLVDFP; -.
DR   OrthoDB; 1517160at2759; -.
DR   TreeFam; TF300196; -.
DR   Reactome; R-BTA-6804114; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000013860; Expressed in bone marrow and 101 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IEA:Ensembl.
DR   GO; GO:0033140; P:negative regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
DR   GO; GO:0071901; P:negative regulation of protein serine/threonine kinase activity; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:1900745; P:positive regulation of p38MAPK cascade; IEA:Ensembl.
DR   GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
DR   GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0042770; P:signal transduction in response to DNA damage; IEA:Ensembl.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR024824; GADD45.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   PANTHER; PTHR10411; PTHR10411; 1.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; DNA damage; Growth arrest; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..165
FT                   /note="Growth arrest and DNA damage-inducible protein
FT                   GADD45 alpha"
FT                   /id="PRO_0000228616"
FT   MOD_RES         2
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P24522"
SQ   SEQUENCE   165 AA;  18337 MW;  FFCDCCE3F6C85AC6 CRC64;
     MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA
     ADEDDDRDVA LQIHFTLIQA FCCENDIDIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP
     DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER