ID   GA45A_CRIGR             Reviewed;         165 AA.
AC   P24523;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Growth arrest and DNA damage-inducible protein GADD45 alpha;
DE   AltName: Full=DNA damage-inducible transcript 1 protein;
DE            Short=DDIT-1;
GN   Name=GADD45A; Synonyms=DDIT1, GADD45;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RX   PubMed=1990262; DOI=10.1128/mcb.11.2.1009-1016.1991;
RA   Papathanasiou M.A., Kerr N.C.K., Robbins J.H., McBride O.W., Alamo I. Jr.,
RA   Barrett S.F., Hickson I.D., Fornace A.J. Jr.;
RT   "Induction by ionizing radiation of the gadd45 gene in cultured human
RT   cells: lack of mediation by protein kinase C.";
RL   Mol. Cell. Biol. 11:1009-1016(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Ovary;
RX   PubMed=8226988; DOI=10.1016/s0021-9258(20)80537-7;
RA   Hollander M.C., Alamo I. Jr., Jackman J., Wang M.G., McBride O.W.,
RA   Fornace A.J. Jr.;
RT   "Analysis of the mammalian gadd45 gene and its response to DNA damage.";
RL   J. Biol. Chem. 268:24385-24393(1993).
CC   -!- FUNCTION: Might affect PCNA interaction with some CDK (cell division
CC       protein kinase) complexes; stimulates DNA excision repair in vitro and
CC       inhibits entry of cells into S phase. In T-cells, functions as a
CC       regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with AURKA, PCNA, GADD45GIP1 and MAPK14.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- INDUCTION: By UV radiation, X-rays, growth arrest and alkylating
CC       agents. The induction is mediate by some kinase(s) other than PKC.
CC       {ECO:0000269|PubMed:1990262}.
CC   -!- SIMILARITY: Belongs to the GADD45 family. {ECO:0000305}.
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DR   EMBL; M60973; AAA36984.1; -; mRNA.
DR   EMBL; L25339; AAA62760.1; -; Genomic_DNA.
DR   PIR; I48111; I48111.
DR   AlphaFoldDB; P24523; -.
DR   SMR; P24523; -.
DR   STRING; 10029.XP_007607467.1; -.
DR   Ensembl; ENSCGRT00001029383; ENSCGRP00001025137; ENSCGRG00001022826.
DR   eggNOG; ENOG502RY8P; Eukaryota.
DR   GeneTree; ENSGT00950000182964; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR   GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0007098; P:centrosome cycle; IEA:Ensembl.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IEA:Ensembl.
DR   GO; GO:0033140; P:negative regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
DR   GO; GO:0071901; P:negative regulation of protein serine/threonine kinase activity; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:1900745; P:positive regulation of p38MAPK cascade; IEA:Ensembl.
DR   GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR   GO; GO:0042770; P:signal transduction in response to DNA damage; IEA:Ensembl.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR024824; GADD45.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   PANTHER; PTHR10411; PTHR10411; 1.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; DNA damage; Growth arrest; Nucleus; Phosphoprotein.
FT   CHAIN           1..165
FT                   /note="Growth arrest and DNA damage-inducible protein
FT                   GADD45 alpha"
FT                   /id="PRO_0000148330"
FT   MOD_RES         2
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P24522"
SQ   SEQUENCE   165 AA;  18296 MW;  580A583484846D38 CRC64;
     MTLEEFSAAE QKTERMDTVG DALEEVLSKA RSQRTITVGV YEAAKLLNVD PDNVVLCLLA
     ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLESDAGP AESGGASQPP
     DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER