GA45B_BOVIN
ID GA45B_BOVIN Reviewed; 160 AA.
AC Q5E9A5;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Growth arrest and DNA damage-inducible protein GADD45 beta;
GN Name=GADD45B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the regulation of growth and apoptosis. Mediates
CC activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with GADD45GIP1. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GADD45 family. {ECO:0000305}.
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DR EMBL; BT021015; AAX09032.1; -; mRNA.
DR EMBL; BC113347; AAI13348.1; -; mRNA.
DR RefSeq; NP_001035694.1; NM_001040604.1.
DR AlphaFoldDB; Q5E9A5; -.
DR SMR; Q5E9A5; -.
DR STRING; 9913.ENSBTAP00000035670; -.
DR PaxDb; Q5E9A5; -.
DR PRIDE; Q5E9A5; -.
DR Ensembl; ENSBTAT00000035803; ENSBTAP00000035670; ENSBTAG00000025462.
DR GeneID; 618405; -.
DR KEGG; bta:618405; -.
DR CTD; 4616; -.
DR VEuPathDB; HostDB:ENSBTAG00000025462; -.
DR VGNC; VGNC:29207; GADD45B.
DR eggNOG; ENOG502RY00; Eukaryota.
DR GeneTree; ENSGT00950000182964; -.
DR HOGENOM; CLU_118164_0_0_1; -.
DR InParanoid; Q5E9A5; -.
DR OMA; YCEESRE; -.
DR OrthoDB; 1517160at2759; -.
DR TreeFam; TF300196; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000025462; Expressed in intramuscular adipose tissue and 103 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR024824; GADD45.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR PANTHER; PTHR10411; PTHR10411; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR SUPFAM; SSF55315; SSF55315; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Developmental protein; Differentiation; Reference proteome.
FT CHAIN 1..160
FT /note="Growth arrest and DNA damage-inducible protein
FT GADD45 beta"
FT /id="PRO_0000228618"
SQ SEQUENCE 160 AA; 17806 MW; 4C6D9A18830F2DA8 CRC64;
MTLEELVACD NAAQKMQTVS AAVEELLVAA QLQDRLTVGV YESAKLMNVD PDSVVLCLLA
IDEEEEDDIA LQIHFTLIQS FCCENDIDIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL
LVTNPHTDTW KSHGLVEVAS YCEESRGNNQ WVPYISLQER
