GA45B_HUMAN
ID GA45B_HUMAN Reviewed; 160 AA.
AC O75293; A8KAM2; O75960; Q17R46;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Growth arrest and DNA damage-inducible protein GADD45 beta;
DE AltName: Full=Myeloid differentiation primary response protein MyD118;
DE AltName: Full=Negative growth regulatory protein MyD118;
GN Name=GADD45B; Synonyms=MYD118;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung carcinoma;
RA Sakaue M., Adachi H., Jetten A.M.;
RT "Posttranscriptional regulation of MyD118 and GADD45 during apoptosis in
RT human lung carcinoma cell lines by the synthetic retinoid AHPN.";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9827804; DOI=10.1016/s0092-8674(00)81619-0;
RA Takekawa M., Saito H.;
RT "A family of stress-inducible GADD45-like proteins mediate activation of
RT the stress-responsive MTK1/MEKK4 MAPKKK.";
RL Cell 95:521-530(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10773677; DOI=10.1159/000015496;
RA Gong R., Yu L., Zhang H., Tu Q., Zhao Y., Yang J., Xu Y., Zhao S.;
RT "Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation
RT hybrid mapping.";
RL Cytogenet. Cell Genet. 88:95-96(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NIEHS SNPs program;
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP INTERACTION WITH GADD45GIP1.
RC TISSUE=Colon carcinoma;
RX PubMed=12716909; DOI=10.1074/jbc.m212835200;
RA Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C.,
RA Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I.,
RA Shong M.;
RT "CR6-interacting factor 1 interacts with Gadd45 family proteins and
RT modulates the cell cycle.";
RL J. Biol. Chem. 278:28079-28088(2003).
CC -!- FUNCTION: Involved in the regulation of growth and apoptosis. Mediates
CC activation of stress-responsive MTK1/MEKK4 MAPKKK.
CC -!- SUBUNIT: Interacts with GADD45GIP1. {ECO:0000269|PubMed:12716909}.
CC -!- INTERACTION:
CC O75293; Q92600-3: CNOT9; NbExp=3; IntAct=EBI-448187, EBI-12907584;
CC O75293; Q5JVL4: EFHC1; NbExp=5; IntAct=EBI-448187, EBI-743105;
CC O75293; O14733: MAP2K7; NbExp=8; IntAct=EBI-448187, EBI-492605;
CC O75293; Q9Y6R4: MAP3K4; NbExp=2; IntAct=EBI-448187, EBI-448104;
CC -!- SIMILARITY: Belongs to the GADD45 family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/gadd45b/";
CC -!- WEB RESOURCE: Name=Wikipedia; Note=GADD45B entry;
CC URL="https://en.wikipedia.org/wiki/GADD45B";
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DR EMBL; AF090950; AAC36361.1; -; mRNA.
DR EMBL; AF078077; AAC83328.1; -; mRNA.
DR EMBL; AF087853; AAG48366.1; -; mRNA.
DR EMBL; AF533019; AAM92794.1; -; Genomic_DNA.
DR EMBL; AK293087; BAF85776.1; -; mRNA.
DR EMBL; AC005624; AAC34572.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69376.1; -; Genomic_DNA.
DR EMBL; BC113466; AAI13467.1; -; mRNA.
DR EMBL; BC117469; AAI17470.1; -; mRNA.
DR CCDS; CCDS32868.1; -.
DR RefSeq; NP_056490.2; NM_015675.3.
DR AlphaFoldDB; O75293; -.
DR SMR; O75293; -.
DR BioGRID; 110701; 72.
DR CORUM; O75293; -.
DR DIP; DIP-24219N; -.
DR IntAct; O75293; 20.
DR MINT; O75293; -.
DR STRING; 9606.ENSP00000215631; -.
DR iPTMnet; O75293; -.
DR PhosphoSitePlus; O75293; -.
DR BioMuta; GADD45B; -.
DR MassIVE; O75293; -.
DR PaxDb; O75293; -.
DR PeptideAtlas; O75293; -.
DR PRIDE; O75293; -.
DR ProteomicsDB; 49878; -.
DR Antibodypedia; 23027; 171 antibodies from 30 providers.
DR DNASU; 4616; -.
DR Ensembl; ENST00000215631.9; ENSP00000215631.3; ENSG00000099860.9.
DR GeneID; 4616; -.
DR KEGG; hsa:4616; -.
DR MANE-Select; ENST00000215631.9; ENSP00000215631.3; NM_015675.4; NP_056490.2.
DR UCSC; uc002lwb.3; human.
DR CTD; 4616; -.
DR DisGeNET; 4616; -.
DR GeneCards; GADD45B; -.
DR HGNC; HGNC:4096; GADD45B.
DR HPA; ENSG00000099860; Low tissue specificity.
DR MIM; 604948; gene.
DR neXtProt; NX_O75293; -.
DR OpenTargets; ENSG00000099860; -.
DR PharmGKB; PA28511; -.
DR VEuPathDB; HostDB:ENSG00000099860; -.
DR eggNOG; ENOG502RY00; Eukaryota.
DR GeneTree; ENSGT00950000182964; -.
DR HOGENOM; CLU_118164_0_0_1; -.
DR InParanoid; O75293; -.
DR OMA; YCEESRE; -.
DR PhylomeDB; O75293; -.
DR TreeFam; TF300196; -.
DR PathwayCommons; O75293; -.
DR SignaLink; O75293; -.
DR SIGNOR; O75293; -.
DR BioGRID-ORCS; 4616; 26 hits in 1082 CRISPR screens.
DR GeneWiki; GADD45B; -.
DR GenomeRNAi; 4616; -.
DR Pharos; O75293; Tbio.
DR PRO; PR:O75293; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O75293; protein.
DR Bgee; ENSG00000099860; Expressed in vena cava and 210 other tissues.
DR ExpressionAtlas; O75293; baseline and differential.
DR Genevisible; O75293; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; IDA:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR024824; GADD45.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR PANTHER; PTHR10411; PTHR10411; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR SUPFAM; SSF55315; SSF55315; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Developmental protein; Differentiation; Reference proteome.
FT CHAIN 1..160
FT /note="Growth arrest and DNA damage-inducible protein
FT GADD45 beta"
FT /id="PRO_0000148334"
FT CONFLICT 95..96
FT /note="MQ -> NA (in Ref. 1; AAC36361)"
FT /evidence="ECO:0000305"
FT CONFLICT 121..123
FT /note="LVT -> PFLQ (in Ref. 1; AAC36361)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 160 AA; 17818 MW; 52712E307B322D46 CRC64;
MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA
IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL
LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER
