GA45B_MOUSE
ID GA45B_MOUSE Reviewed; 160 AA.
AC P22339; Q3U342; Q9R106;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Growth arrest and DNA damage-inducible protein GADD45 beta;
DE AltName: Full=Myeloid differentiation primary response protein MyD118;
DE AltName: Full=Negative growth regulatory protein MyD118;
GN Name=Gadd45b; Synonyms=Myd118;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1899477;
RA Abdollahi A., Lord K.A., Hoffman-Liebermann B., Liebermann D.A.;
RT "Sequence and expression of a cDNA encoding MyD118: a novel myeloid
RT differentiation primary response gene induced by multiple cytokines.";
RL Oncogene 6:165-167(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=11403721; DOI=10.1089/104454901750219125;
RA Balliet A.G., Hatton K.S., Hoffman B., Liebermann D.A.;
RT "Comparative analysis of the genetic structure and chromosomal location of
RT the murine MyD118 (Gadd45beta) gene.";
RL DNA Cell Biol. 20:239-247(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=12162804; DOI=10.1089/104454902320219059;
RA Jin R., De Smaele E., Zazzeroni F., Nguyen D.U., Papa S., Jones J., Cox C.,
RA Gelinas C., Franzoso G.;
RT "Regulation of the gadd45beta promoter by NF-kappaB.";
RL DNA Cell Biol. 21:491-503(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in the regulation of growth and apoptosis. Mediates
CC activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with GADD45GIP1. {ECO:0000250}.
CC -!- INTERACTION:
CC P22339; Q8TAE8: GADD45GIP1; Xeno; NbExp=3; IntAct=EBI-2266938, EBI-372506;
CC -!- TISSUE SPECIFICITY: In myeloid precursor enriched BM cells.
CC -!- INDUCTION: By cytokines.
CC -!- SIMILARITY: Belongs to the GADD45 family. {ECO:0000305}.
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DR EMBL; X54149; CAA38088.1; -; mRNA.
DR EMBL; AF176045; AAD51080.2; -; Genomic_DNA.
DR EMBL; AF441860; AAN23034.1; -; Genomic_DNA.
DR EMBL; AK010420; BAB26923.1; -; mRNA.
DR EMBL; AK149895; BAE29151.1; -; mRNA.
DR EMBL; AK154952; BAE32947.1; -; mRNA.
DR EMBL; BC023815; AAH23815.1; -; mRNA.
DR CCDS; CCDS24038.1; -.
DR PIR; A43813; A43813.
DR RefSeq; NP_032681.1; NM_008655.1.
DR AlphaFoldDB; P22339; -.
DR SMR; P22339; -.
DR BioGRID; 201638; 8.
DR IntAct; P22339; 2.
DR STRING; 10090.ENSMUSP00000015456; -.
DR PhosphoSitePlus; P22339; -.
DR PaxDb; P22339; -.
DR PRIDE; P22339; -.
DR Antibodypedia; 23027; 171 antibodies from 30 providers.
DR DNASU; 17873; -.
DR Ensembl; ENSMUST00000015456; ENSMUSP00000015456; ENSMUSG00000015312.
DR GeneID; 17873; -.
DR KEGG; mmu:17873; -.
DR UCSC; uc007gfl.1; mouse.
DR CTD; 4616; -.
DR MGI; MGI:107776; Gadd45b.
DR VEuPathDB; HostDB:ENSMUSG00000015312; -.
DR eggNOG; ENOG502RY00; Eukaryota.
DR GeneTree; ENSGT00950000182964; -.
DR HOGENOM; CLU_118164_0_0_1; -.
DR InParanoid; P22339; -.
DR OMA; YCEESRE; -.
DR OrthoDB; 1517160at2759; -.
DR PhylomeDB; P22339; -.
DR TreeFam; TF300196; -.
DR BioGRID-ORCS; 17873; 1 hit in 73 CRISPR screens.
DR PRO; PR:P22339; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; P22339; protein.
DR Bgee; ENSMUSG00000015312; Expressed in skin of snout and 257 other tissues.
DR ExpressionAtlas; P22339; baseline and differential.
DR Genevisible; P22339; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IDA:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISO:MGI.
DR GO; GO:0051726; P:regulation of cell cycle; IDA:MGI.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR024824; GADD45.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR PANTHER; PTHR10411; PTHR10411; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR SUPFAM; SSF55315; SSF55315; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Developmental protein; Differentiation; Reference proteome.
FT CHAIN 1..160
FT /note="Growth arrest and DNA damage-inducible protein
FT GADD45 beta"
FT /id="PRO_0000148335"
SQ SEQUENCE 160 AA; 17783 MW; AD297587576532C5 CRC64;
MTLEELVASD NAVQKMQAVT AAVEQLLVAA QRQDRLTVGV YEAAKLMNVD PDSVVLCLLA
IDEEEEDDIA LQIHFTLIQS FCCDNDIDIV RVSGMQRLAQ LLGEPAETLG TTEARDLHCL
LVTNCHTDSW KSQGLVEVAS YCEESRGNNQ WVPYISLEER
