ID   GA45G_BOVIN             Reviewed;         159 AA.
AC   Q2KIX1;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Growth arrest and DNA damage-inducible protein GADD45 gamma;
GN   Name=GADD45G;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the regulation of growth and apoptosis. Mediates
CC       activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Undergoes concentration-dependent homodimerization, which is
CC       required for growth inhibititory activity and enhances interaction with
CC       PCNA. Interacts with GADD45GIP1. Interacts with PCNA (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Two central helices mediate homodimerization through parallel
CC       packing. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GADD45 family. {ECO:0000305}.
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DR   EMBL; BC112476; AAI12477.1; -; mRNA.
DR   RefSeq; NP_001039366.1; NM_001045901.1.
DR   AlphaFoldDB; Q2KIX1; -.
DR   SMR; Q2KIX1; -.
DR   STRING; 9913.ENSBTAP00000003943; -.
DR   PaxDb; Q2KIX1; -.
DR   GeneID; 504939; -.
DR   KEGG; bta:504939; -.
DR   CTD; 10912; -.
DR   eggNOG; ENOG502RXKU; Eukaryota.
DR   HOGENOM; CLU_118164_0_0_1; -.
DR   InParanoid; Q2KIX1; -.
DR   OrthoDB; 1517160at2759; -.
DR   TreeFam; TF300196; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR024824; GADD45.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   PANTHER; PTHR10411; PTHR10411; 1.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Developmental protein; Differentiation; Reference proteome.
FT   CHAIN           1..159
FT                   /note="Growth arrest and DNA damage-inducible protein
FT                   GADD45 gamma"
FT                   /id="PRO_0000247676"
FT   REGION          43..86
FT                   /note="Homodimerization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   159 AA;  17294 MW;  211BAEB90A768913 CRC64;
     MTLEELRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL NVDPDNVTFC
     VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR LAAIVGTGDE SGAPVDLHCI
     LISNPNEDAW KDPALEKLSL FCEESRSVND WVPNITLPE