GA45G_RAT
ID GA45G_RAT Reviewed; 159 AA.
AC Q9WTQ7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Growth arrest and DNA damage-inducible protein GADD45 gamma;
GN Name=Gadd45g;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10100865; DOI=10.1016/s0014-5793(99)00234-3;
RA Kojima S., Mayumi-Matsuda K., Suzuki H., Sakata T.;
RT "Molecular cloning of rat GADD45gamma, gene induction and its role during
RT neuronal cell death.";
RL FEBS Lett. 446:313-317(1999).
CC -!- FUNCTION: Involved in the regulation of growth and apoptosis. Mediates
CC activation of stress-responsive MTK1/MEKK4 MAPKKK.
CC -!- SUBUNIT: Undergoes concentration-dependent homodimerization, which is
CC required for growth inhibititory activity and enhances interaction with
CC PCNA. Interacts with GADD45GIP1. Interacts with PCNA (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: Two central helices mediate homodimerization through parallel
CC packing. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GADD45 family. {ECO:0000305}.
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DR EMBL; AB020978; BAA78094.1; -; mRNA.
DR RefSeq; NP_001071108.1; NM_001077640.1.
DR AlphaFoldDB; Q9WTQ7; -.
DR SMR; Q9WTQ7; -.
DR STRING; 10116.ENSRNOP00000018251; -.
DR PaxDb; Q9WTQ7; -.
DR Ensembl; ENSRNOT00000018252; ENSRNOP00000018251; ENSRNOG00000013090.
DR GeneID; 291005; -.
DR KEGG; rno:291005; -.
DR CTD; 10912; -.
DR RGD; 1311796; Gadd45g.
DR eggNOG; ENOG502RXKU; Eukaryota.
DR GeneTree; ENSGT00950000182964; -.
DR HOGENOM; CLU_118164_0_0_1; -.
DR InParanoid; Q9WTQ7; -.
DR OMA; SRSAYDW; -.
DR OrthoDB; 1517160at2759; -.
DR PhylomeDB; Q9WTQ7; -.
DR TreeFam; TF300196; -.
DR PRO; PR:Q9WTQ7; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000013090; Expressed in skeletal muscle tissue and 19 other tissues.
DR ExpressionAtlas; Q9WTQ7; baseline and differential.
DR Genevisible; Q9WTQ7; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; ISO:RGD.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:RGD.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISO:RGD.
DR GO; GO:0051726; P:regulation of cell cycle; ISO:RGD.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR024824; GADD45.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR PANTHER; PTHR10411; PTHR10411; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR SUPFAM; SSF55315; SSF55315; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Developmental protein; Differentiation; Reference proteome.
FT CHAIN 1..159
FT /note="Growth arrest and DNA damage-inducible protein
FT GADD45 gamma"
FT /id="PRO_0000148338"
FT REGION 43..86
FT /note="Homodimerization"
FT /evidence="ECO:0000250"
SQ SEQUENCE 159 AA; 17287 MW; 4B598B339E45CD96 CRC64;
MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL NVDPDNVTFC
VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR LAAIVGADDE GGAPGDLHCI
LISNPNEDTW KDPALEKLSL FCEESRSFND WVPSITLPE
