GAB4_HUMAN
ID GAB4_HUMAN Reviewed; 574 AA.
AC Q2WGN9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=GRB2-associated-binding protein 4;
DE AltName: Full=GRB2-associated binder 2-like;
DE Short=GAB2-like;
DE AltName: Full=GRB2-associated binder 4;
DE AltName: Full=GRB2-associated-binding protein 2-like;
DE AltName: Full=Growth factor receptor bound protein 2-associated protein 4;
GN Name=GAB4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Shimizu N., Minoshima S., Sasaki T., Hosono K.;
RT "Identification and cDNA cloning of Grb2 associated binder 2 (GAB2)-like.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GAB family. {ECO:0000305}.
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DR EMBL; AB076978; BAD06454.1; -; mRNA.
DR CCDS; CCDS42976.1; -.
DR RefSeq; NP_001032903.1; NM_001037814.1.
DR AlphaFoldDB; Q2WGN9; -.
DR SMR; Q2WGN9; -.
DR BioGRID; 126176; 1.
DR IntAct; Q2WGN9; 1.
DR STRING; 9606.ENSP00000383431; -.
DR iPTMnet; Q2WGN9; -.
DR PhosphoSitePlus; Q2WGN9; -.
DR BioMuta; GAB4; -.
DR DMDM; 121947654; -.
DR MassIVE; Q2WGN9; -.
DR PaxDb; Q2WGN9; -.
DR PeptideAtlas; Q2WGN9; -.
DR PRIDE; Q2WGN9; -.
DR ProteomicsDB; 61538; -.
DR Antibodypedia; 50150; 131 antibodies from 21 providers.
DR DNASU; 128954; -.
DR Ensembl; ENST00000400588.5; ENSP00000383431.1; ENSG00000215568.9.
DR GeneID; 128954; -.
DR KEGG; hsa:128954; -.
DR MANE-Select; ENST00000400588.5; ENSP00000383431.1; NM_001037814.1; NP_001032903.1.
DR UCSC; uc002zlw.4; human.
DR CTD; 128954; -.
DR GeneCards; GAB4; -.
DR HGNC; HGNC:18325; GAB4.
DR HPA; ENSG00000215568; Tissue enriched (testis).
DR neXtProt; NX_Q2WGN9; -.
DR PharmGKB; PA134933290; -.
DR VEuPathDB; HostDB:ENSG00000215568; -.
DR eggNOG; KOG3751; Eukaryota.
DR GeneTree; ENSGT00940000164938; -.
DR HOGENOM; CLU_028652_0_0_1; -.
DR InParanoid; Q2WGN9; -.
DR OrthoDB; 1153633at2759; -.
DR PhylomeDB; Q2WGN9; -.
DR TreeFam; TF329487; -.
DR SignaLink; Q2WGN9; -.
DR BioGRID-ORCS; 128954; 20 hits in 1062 CRISPR screens.
DR ChiTaRS; GAB4; human.
DR GenomeRNAi; 128954; -.
DR Pharos; Q2WGN9; Tdark.
DR PRO; PR:Q2WGN9; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q2WGN9; protein.
DR Bgee; ENSG00000215568; Expressed in left testis and 44 other tissues.
DR ExpressionAtlas; Q2WGN9; baseline and differential.
DR Genevisible; Q2WGN9; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR046355; Gab1-4-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45960; PTHR45960; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..574
FT /note="GRB2-associated-binding protein 4"
FT /id="PRO_0000271192"
FT DOMAIN 39..152
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 273
FT /note="L -> P (in dbSNP:rs11703655)"
FT /id="VAR_053098"
SQ SEQUENCE 574 AA; 62367 MW; F504C5CDF34C592C CRC64;
MSLPSPSPSR ELCPPDPAFA PLSSWPGSGP AGGSTRSGHV LYSGWLRKSP PEKKLRLFAW
RKRWFILRRG QTSSDPDVLE YYKNDGSKKP LRTINLNLCE QLDVDVTLNF NKKEIQKGYM
FDIKTSERTF YLVAETREDM NEWVQSICQI CGFRQEESTG FLGNISSASH GLCSSPAEPS
CSHQHLPQEQ EPTSEPPVSH CVPPTWPIPA PPGCLRSHQH ASQRAEHARS ASFSQGSEAP
FIMRRNTAMQ NLAQHSGYSV DGVSGHIHGF HSLSKPSQHN AEFRGSTHRI PWSLASHGHT
RGSLTGSEAD NEASSGKYTQ HGGGNASRPA ESMHEGVCSF LPGRTLVGLS DSIASEGSCV
PMNPGSPTLP AVKQAGDDSQ GVCIPVGSCL VRFDLLGSPL TELSMHQDLS QGHEVQLPPV
NRSLKPNQKA NPTPPNLRNN RVINELSFKP PVTEPWSGTS HTFDSSSSQH PISTQSITNT
DSEDSGERYL FPNPASAFPV SGGTSSSAPP RSTGNIHYAA LDFQPSKPSI GSVTSGKKVD
YVQVDLEKTQ ALQKTMHEQM CLRQSSEPPR GAKL
