ID   GABD_SINFN              Reviewed;         491 AA.
AC   P55653;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Probable succinate-semialdehyde dehydrogenase [NADP(+)];
DE            Short=SSDH;
DE            EC=1.2.1.79;
GN   Name=gabD; OrderedLocusNames=NGR_a01630; ORFNames=y4sJ;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG   Plasmid sym pNGR234a.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=9163424; DOI=10.1038/387394a0;
RA   Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA   Perret X.;
RT   "Molecular basis of symbiosis between Rhizobium and legumes.";
RL   Nature 387:394-401(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Catalyzes the NADP(+) dependent oxidation of succinate
CC       semialdehyde to succinate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH +
CC         succinate; Xref=Rhea:RHEA:13213, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30031, ChEBI:CHEBI:57706,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.2.1.79;
CC   -!- PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; U00090; AAB91849.1; -; Genomic_DNA.
DR   PIR; S43963; S43963.
DR   RefSeq; NP_444062.1; NC_000914.2.
DR   RefSeq; WP_010875199.1; NC_000914.2.
DR   AlphaFoldDB; P55653; -.
DR   SMR; P55653; -.
DR   STRING; 394.NGR_a01630; -.
DR   PRIDE; P55653; -.
DR   EnsemblBacteria; AAB91849; AAB91849; NGR_a01630.
DR   KEGG; rhi:NGR_a01630; -.
DR   PATRIC; fig|394.7.peg.153; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_5_1_5; -.
DR   OMA; RRCFELM; -.
DR   OrthoDB; 384611at2; -.
DR   UniPathway; UPA00733; -.
DR   Proteomes; UP000001054; Plasmid sym pNGR234a.
DR   GO; GO:0036243; F:succinate-semialdehyde dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009450; P:gamma-aminobutyric acid catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR010102; Succ_semiAld_DH.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   TIGRFAMs; TIGR01780; SSADH; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Plasmid; Reference proteome.
FT   CHAIN           1..491
FT                   /note="Probable succinate-semialdehyde dehydrogenase
FT                   [NADP(+)]"
FT                   /id="PRO_0000056573"
FT   ACT_SITE        263
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        297
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   BINDING         163..164
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         187..190
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         241..242
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         264
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         394
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   491 AA;  53254 MW;  FC54C5DF7B4D1B14 CRC64;
     MTLTSALTRH LKCPELFRNL ANEPHPSVAG QRQRFSVFNP STGELLAEVP DMGAADAHAA
     IERADAAQEP WSGLTARARS DILWKWHRFI LEHSDDLAAI LTAEMGKPLG EAKSEVQHAA
     AYLQWYAEEA NRIYGETISA PSTDRRMLVI KQPIGVVGAI TPWNFPASMV ARKISPALAA
     GCTVVLKPAE QTPLVAGAMF ALAKLAGFPD GVLNLVYASE GDAIGRELCT NPKVRKISFT
     GSTEVGRLLM RQCSDQIKRI SFELGGNAPF IVFDDADIDA AVDGAIQAKF RNAGQTCVSA
     NRIYVQSGVY AEFAEKFTER VRTLKVGDGF DPNVAIGPLI NQEALKKIEL HISDAVQKGA
     RVRSGGRRTG SSGTFFEPTV VTDVSKTMRL AEEETFGPLA PLLRFDDADH VVREANDTIY
     GLAAYFYASN LKRVWRVAEA LEYGMVGINT GRMSSEAAPF GGVKQSGIGR EGSRHGLEDY
     LDMKYLCVGG L