ID   GABP2_BOVIN             Reviewed;         447 AA.
AC   Q0V8G2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=GA-binding protein subunit beta-2;
DE            Short=GABP subunit beta-2;
DE            Short=GABPB-2;
GN   Name=GABPB2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: May function as transcription factor capable of interacting
CC       with purine rich repeats (GA repeats). {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits. The C-
CC       terminal is necessary for the formation of a heterotetrameric GABP-
CC       alpha-2/beta-2 complex, and also facilitates homotypic dimerization.
CC       Interacts with ADGRB2. {ECO:0000250|UniProtKB:P81069}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q0V8G2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q0V8G2-2; Sequence=VSP_032472;
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DR   EMBL; BT026256; ABG67095.1; -; mRNA.
DR   RefSeq; NP_001069710.1; NM_001076242.1. [Q0V8G2-2]
DR   RefSeq; XP_010801344.1; XM_010803042.2. [Q0V8G2-1]
DR   AlphaFoldDB; Q0V8G2; -.
DR   SMR; Q0V8G2; -.
DR   STRING; 9913.ENSBTAP00000020429; -.
DR   PaxDb; Q0V8G2; -.
DR   PRIDE; Q0V8G2; -.
DR   Ensembl; ENSBTAT00000020429; ENSBTAP00000020429; ENSBTAG00000015371. [Q0V8G2-1]
DR   Ensembl; ENSBTAT00000033798; ENSBTAP00000033707; ENSBTAG00000015371. [Q0V8G2-2]
DR   GeneID; 540818; -.
DR   KEGG; bta:540818; -.
DR   CTD; 126626; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015371; -.
DR   eggNOG; ENOG502QRTX; Eukaryota.
DR   GeneTree; ENSGT00940000156794; -.
DR   HOGENOM; CLU_000134_12_0_1; -.
DR   InParanoid; Q0V8G2; -.
DR   OMA; QVNTHPE; -.
DR   OrthoDB; 1514706at2759; -.
DR   TreeFam; TF326036; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000015371; Expressed in neutrophil and 109 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF13637; Ank_4; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ANK repeat; Coiled coil; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..447
FT                   /note="GA-binding protein subunit beta-2"
FT                   /id="PRO_0000325907"
FT   REPEAT          5..34
FT                   /note="ANK 1"
FT   REPEAT          37..66
FT                   /note="ANK 2"
FT   REPEAT          70..99
FT                   /note="ANK 3"
FT   REPEAT          103..132
FT                   /note="ANK 4"
FT   REPEAT          136..166
FT                   /note="ANK 5"
FT   REGION          418..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          345..395
FT                   /evidence="ECO:0000255"
FT   MOD_RES         253
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P81069"
FT   VAR_SEQ         1..36
FT                   /note="MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDW -> MSIISPQ (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_032472"
SQ   SEQUENCE   447 AA;  48475 MW;  A98390D9FA023C76 CRC64;
     MSLVDLGKRL LEAARKGQDD EVRTLMANGA PFTTDWLGTS PLHLAAQYGH YSTAEVLLRA
     GVSRDARTKV DRTPLHMAAA DGHAHIVELL VRNGADVNAK DMLKMTALHW ATEHHHRDVV
     ELLIKYGADV HAFSKFDKSA FDIALEKNNA EILVILQEAM QNQVNANPER ANPVTMATPF
     IFTSGEVVNL ASLVSSASTK TTSGDPHASS TVHFSNSTTS VLATLAALAE ASAPLSNSHR
     ATANSEEIIE GNSVDSSIQQ VVGSGGQRVI TIVTDGIPLG NIQTAIPAGG IGQPFIVTVQ
     DGQQVLTVPA GQVAEETVIE EEAEEAEKLP LTKKPRIEEM TNSVEESKEG TERELLQQRL
     QEANRRAQEY RHQLLKKEQE AEQYRLRLEA MARQQPNGVD FAMVEEVAEV DAVVVTEREM
     EERETEVTGA VGTAEPHTGV SMETVST