GABP2_HUMAN
ID GABP2_HUMAN Reviewed; 448 AA.
AC Q8TAK5; B1AVJ8; D3DV14; Q8NAR5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=GA-binding protein subunit beta-2;
DE Short=GABP subunit beta-2;
DE Short=GABPB-2;
GN Name=GABPB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as transcription factor capable of interacting
CC with purine rich repeats (GA repeats). {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits. The C-
CC terminal is necessary for the formation of a heterotetrameric GABP-
CC alpha-2/beta-2 complex, and also facilitates homotypic dimerization.
CC Interacts with ADGRB2. {ECO:0000250|UniProtKB:P81069}.
CC -!- INTERACTION:
CC Q8TAK5; P21333-2: FLNA; NbExp=3; IntAct=EBI-8468945, EBI-9641086;
CC Q8TAK5; Q06546: GABPA; NbExp=4; IntAct=EBI-8468945, EBI-638925;
CC Q8TAK5; Q9H8Y8: GORASP2; NbExp=6; IntAct=EBI-8468945, EBI-739467;
CC Q8TAK5; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-8468945, EBI-2341787;
CC Q8TAK5; Q8N2W9: PIAS4; NbExp=3; IntAct=EBI-8468945, EBI-473160;
CC Q8TAK5; P08579: SNRPB2; NbExp=3; IntAct=EBI-8468945, EBI-1053651;
CC Q8TAK5; Q8NCE0: TSEN2; NbExp=3; IntAct=EBI-8468945, EBI-2559818;
CC Q8TAK5; Q08AM6: VAC14; NbExp=3; IntAct=EBI-8468945, EBI-2107455;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK092230; BAC03833.1; -; mRNA.
DR EMBL; AL691467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL592424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW53474.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53475.1; -; Genomic_DNA.
DR EMBL; BC027033; AAH27033.1; -; mRNA.
DR CCDS; CCDS983.1; -.
DR RefSeq; NP_001310837.1; NM_001323908.1.
DR RefSeq; NP_653219.1; NM_144618.2.
DR RefSeq; XP_016855738.1; XM_017000249.1.
DR AlphaFoldDB; Q8TAK5; -.
DR SMR; Q8TAK5; -.
DR BioGRID; 126004; 13.
DR CORUM; Q8TAK5; -.
DR IntAct; Q8TAK5; 14.
DR MINT; Q8TAK5; -.
DR STRING; 9606.ENSP00000357914; -.
DR GlyGen; Q8TAK5; 5 sites, 1 O-linked glycan (5 sites).
DR iPTMnet; Q8TAK5; -.
DR PhosphoSitePlus; Q8TAK5; -.
DR BioMuta; GABPB2; -.
DR DMDM; 74751355; -.
DR EPD; Q8TAK5; -.
DR jPOST; Q8TAK5; -.
DR MassIVE; Q8TAK5; -.
DR MaxQB; Q8TAK5; -.
DR PaxDb; Q8TAK5; -.
DR PeptideAtlas; Q8TAK5; -.
DR PRIDE; Q8TAK5; -.
DR ProteomicsDB; 73888; -.
DR Antibodypedia; 34049; 257 antibodies from 26 providers.
DR DNASU; 126626; -.
DR Ensembl; ENST00000368918.8; ENSP00000357914.3; ENSG00000143458.12.
DR GeneID; 126626; -.
DR KEGG; hsa:126626; -.
DR MANE-Select; ENST00000368918.8; ENSP00000357914.3; NM_144618.3; NP_653219.1.
DR UCSC; uc001ewr.3; human.
DR CTD; 126626; -.
DR DisGeNET; 126626; -.
DR GeneCards; GABPB2; -.
DR HGNC; HGNC:28441; GABPB2.
DR HPA; ENSG00000143458; Low tissue specificity.
DR neXtProt; NX_Q8TAK5; -.
DR OpenTargets; ENSG00000143458; -.
DR PharmGKB; PA164741559; -.
DR VEuPathDB; HostDB:ENSG00000143458; -.
DR eggNOG; ENOG502QRTX; Eukaryota.
DR GeneTree; ENSGT00940000156794; -.
DR InParanoid; Q8TAK5; -.
DR OMA; QVNTHPE; -.
DR OrthoDB; 1514706at2759; -.
DR PhylomeDB; Q8TAK5; -.
DR TreeFam; TF326036; -.
DR PathwayCommons; Q8TAK5; -.
DR SignaLink; Q8TAK5; -.
DR SIGNOR; Q8TAK5; -.
DR BioGRID-ORCS; 126626; 40 hits in 1081 CRISPR screens.
DR ChiTaRS; GABPB2; human.
DR GenomeRNAi; 126626; -.
DR Pharos; Q8TAK5; Tbio.
DR PRO; PR:Q8TAK5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TAK5; protein.
DR Bgee; ENSG00000143458; Expressed in oviduct epithelium and 182 other tissues.
DR ExpressionAtlas; Q8TAK5; baseline and differential.
DR Genevisible; Q8TAK5; HS.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW ANK repeat; Coiled coil; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation.
FT CHAIN 1..448
FT /note="GA-binding protein subunit beta-2"
FT /id="PRO_0000325908"
FT REPEAT 5..34
FT /note="ANK 1"
FT REPEAT 37..66
FT /note="ANK 2"
FT REPEAT 70..99
FT /note="ANK 3"
FT REPEAT 103..132
FT /note="ANK 4"
FT REPEAT 136..166
FT /note="ANK 5"
FT REGION 325..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 345..395
FT /evidence="ECO:0000255"
FT COMPBIAS 430..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P81069"
FT VARIANT 62
FT /note="V -> I (in dbSNP:rs11204774)"
FT /id="VAR_039950"
FT CONFLICT 13
FT /note="A -> S (in Ref. 1; BAC03833)"
FT /evidence="ECO:0000305"
FT CONFLICT 144
FT /note="A -> S (in Ref. 1; BAC03833)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 448 AA; 48650 MW; DB0940BDDBF499C0 CRC64;
MSLVDLGKRL LEAARKGQDD EVRTLMANGA PFTTDWLGTS PLHLAAQYGH YSTAEVLLRA
GVSRDARTKV DRTPLHMAAA DGHAHIVELL VRNGADVNAK DMLKMTALHW ATERHHRDVV
ELLIKYGADV HAFSKFDKSA FDIALEKNNA EILVILQEAM QNQVNVNPER ANPVTDPVSM
AAPFIFTSGE VVNLASLISS TNTKTTSGDP HASTVQFSNS TTSVLATLAA LAEASVPLSN
SHRATANTEE IIEGNSVDSS IQQVMGSGGQ RVITIVTDGV PLGNIQTSIP TGGIGQPFIV
TVQDGQQVLT VPAGKVAEET VIKEEEEEKL PLTKKPRIGE KTNSVEESKE GNERELLQQQ
LQEANRRAQE YRHQLLKKEQ EAEQYRLKLE AIARQQPNGV DFTMVEEVAE VDAVVVTEGE
LEERETKVTG SAGTTEPHTR VSMATVSS
