ID   GACA_DICDI              Reviewed;         338 AA.
AC   Q54Y72;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Rho GTPase-activating protein gacA;
DE   AltName: Full=GTPase activating factor for raC protein A;
GN   Name=gacA; ORFNames=DDB_G0278381;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AAFI02000023; EAL68363.1; -; Genomic_DNA.
DR   RefSeq; XP_642330.1; XM_637238.1.
DR   AlphaFoldDB; Q54Y72; -.
DR   SMR; Q54Y72; -.
DR   STRING; 44689.DDB0233873; -.
DR   PaxDb; Q54Y72; -.
DR   EnsemblProtists; EAL68363; EAL68363; DDB_G0278381.
DR   GeneID; 8621536; -.
DR   KEGG; ddi:DDB_G0278381; -.
DR   dictyBase; DDB_G0278381; gacA.
DR   eggNOG; KOG4270; Eukaryota.
DR   HOGENOM; CLU_859045_0_0_1; -.
DR   InParanoid; Q54Y72; -.
DR   OMA; CVQFLHN; -.
DR   PhylomeDB; Q54Y72; -.
DR   PRO; PR:Q54Y72; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR044785; RopGAP1-5.
DR   PANTHER; PTHR23177; PTHR23177; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..338
FT                   /note="Rho GTPase-activating protein gacA"
FT                   /id="PRO_0000380193"
FT   DOMAIN          149..327
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
SQ   SEQUENCE   338 AA;  37487 MW;  47E77B538F64AB41 CRC64;
     MGSSSSKSSS SVTVASSIDY KAKPTIDELG TSNYSGGLEV SKNLLDFNLG EKPCPLKSVV
     QDQFTISNSS KTKLKFHFEP LQPKEFQLSF SPTSGSLDKG KSKTIKVKLM VNQKINTNHK
     VVLRVEGGAS HFLTVKIRCE TGVFGVDPNT LEHVEDEGFR VPYILALMKR SLIDNGGLQQ
     EGIFRLAGEQ TEIKRLKEAM NRNDFTSSTD INTVASLIKI WYRELPTPIL NSIPTEKIFY
     STDIDECVQS AKNLPEPQKS LLDWLMHLLL MVSSFSDVNK MTAQNLAIVV APNLYDVSSS
     NPMEGLVLSQ KCVQFLHNVL SHKVAVHKRE SVAYEVLS