ID   GACB_DICDI              Reviewed;         273 AA.
AC   Q54XW7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Rho GTPase-activating protein gacB;
DE   AltName: Full=GTPase activating factor for raC protein B;
GN   Name=gacB; ORFNames=DDB_G0278549;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000023; EAL68447.1; -; Genomic_DNA.
DR   RefSeq; XP_642435.1; XM_637343.1.
DR   AlphaFoldDB; Q54XW7; -.
DR   SMR; Q54XW7; -.
DR   PaxDb; Q54XW7; -.
DR   EnsemblProtists; EAL68447; EAL68447; DDB_G0278549.
DR   GeneID; 8621641; -.
DR   KEGG; ddi:DDB_G0278549; -.
DR   dictyBase; DDB_G0278549; gacB.
DR   eggNOG; ENOG502RCUZ; Eukaryota.
DR   HOGENOM; CLU_1020941_0_0_1; -.
DR   InParanoid; Q54XW7; -.
DR   OMA; STIMEFE; -.
DR   PhylomeDB; Q54XW7; -.
DR   PRO; PR:Q54XW7; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..273
FT                   /note="Rho GTPase-activating protein gacB"
FT                   /id="PRO_0000380194"
FT   DOMAIN          1..192
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
SQ   SEQUENCE   273 AA;  32415 MW;  7C56064C4852E785 CRC64;
     MTDQTLRLEN VSPYLLLILD YFEKNCINKT DLFSIQGNQE NVNRIISNIK NFTPTKQFEK
     DLNRGLYSRH DLSFSIINIL NSLNHPLLLE NYNEAYIVNA YYEDIERIKQ TLLELPHSNL
     EIILKLFSTF NLLCNQEEHK SFLLLSPEML GETFAFVLMR FKKTKDEVDQ FGNKIFATNV
     ISYLISHFNE IFDSTILDFE QKEKKSRENA ILFMEYAMRK YTSLDNHFKS IYNKYIPHKR
     DLSQEDVQTI KTEFNLRKYS GKSKIRPPIP IYM