GACC_DICDI
ID GACC_DICDI Reviewed; 399 AA.
AC Q54PG5;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Rho GTPase-activating protein gacC;
DE AltName: Full=GTPase activating factor for raC protein C;
GN Name=gacC; ORFNames=DDB_G0284571;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AAFI02000066; EAL65154.1; -; Genomic_DNA.
DR RefSeq; XP_638509.1; XM_633417.1.
DR AlphaFoldDB; Q54PG5; -.
DR SMR; Q54PG5; -.
DR STRING; 44689.DDB0233845; -.
DR PaxDb; Q54PG5; -.
DR EnsemblProtists; EAL65154; EAL65154; DDB_G0284571.
DR GeneID; 8624659; -.
DR KEGG; ddi:DDB_G0284571; -.
DR dictyBase; DDB_G0284571; gacC.
DR eggNOG; KOG1809; Eukaryota.
DR eggNOG; KOG3565; Eukaryota.
DR HOGENOM; CLU_691570_0_0_1; -.
DR InParanoid; Q54PG5; -.
DR OMA; VACIFKS; -.
DR PhylomeDB; Q54PG5; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR Reactome; R-DDI-9013424; RHOV GTPase cycle.
DR PRO; PR:Q54PG5; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR015412; Autophagy-rel_C.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF09333; ATG_C; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..399
FT /note="Rho GTPase-activating protein gacC"
FT /id="PRO_0000380195"
FT DOMAIN 186..375
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 43912 MW; C1996926F261EFD3 CRC64;
MESKDQNVYR KGSDNFSKGS NTFFGNLKSI STTTTTTTTT ANTDQQVSKV AENNEIDDNS
SVDSSSSNPS SSSTSTTPVK PKTFVDGALR GVWSIGVGVV NGAKGIVEQP YLGAKNNGLG
GFVKGVAKGV SGVVILPAVG VLEFFSYTTQ GIYNTPITVL DAMKSSPKEE EMITVSAEIP
TIFFAVELEE SFKTAKEKGI PHLLKVCIEF ISRRKNIEGI FRISGSKFLI DEIQSKFDKG
LITSVEDLDP NWIYEVACIF KSYFRYLPHS VIPDEQITEF YRIQNNITDA TEKAAALKAV
VNSIPNFQYT ILYECISLLH DISLNSKENL MTPSNLSIVY GPSLLRPNIE KGDIQEIANA
NTIVFNLISF FQQIFIKNPD PSILEIEHPI TPIKPMIQK