ID   GACE_DICDI              Reviewed;        1132 AA.
AC   Q54BF1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Rho GTPase-activating protein gacE;
DE   AltName: Full=GTPase activating factor for raC protein E;
GN   Name=gacE; ORFNames=DDB_G0293654;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AAFI02000218; EAL60639.1; -; Genomic_DNA.
DR   RefSeq; XP_629078.1; XM_629076.1.
DR   AlphaFoldDB; Q54BF1; -.
DR   SMR; Q54BF1; -.
DR   STRING; 44689.DDB0233872; -.
DR   PaxDb; Q54BF1; -.
DR   PRIDE; Q54BF1; -.
DR   EnsemblProtists; EAL60639; EAL60639; DDB_G0293654.
DR   GeneID; 8629370; -.
DR   KEGG; ddi:DDB_G0293654; -.
DR   dictyBase; DDB_G0293654; gacE.
DR   eggNOG; KOG1450; Eukaryota.
DR   HOGENOM; CLU_278914_0_0_1; -.
DR   InParanoid; Q54BF1; -.
DR   OMA; IICLICE; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR   Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR   Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR   Reactome; R-DDI-9013424; RHOV GTPase cycle.
DR   PRO; PR:Q54BF1; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..1132
FT                   /note="Rho GTPase-activating protein gacE"
FT                   /id="PRO_0000380197"
FT   DOMAIN          76..262
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          279..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          472..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1132 AA;  126778 MW;  A6DD09508463E1C8 CRC64;
     MDHRKSVDFT NEYIKQQTEN QNHTPRGHRM MANFTIRKWN SETNFNEDDY GAIPTKSSIA
     NLLNKFLKSR PTKDDLEMNK ILKSEYKPIT LRYSLIEILC NHIEKYALEQ EGIFRVSGSN
     QQIRLFWQTF TTDNIEFPIN EHNVAGALKL YIREQSEPLV PYEMFSNFIS QLGDGGPVTF
     TAITNLMSKI TPENLKIIKR LIRTAVIIVR HSQLNKMDAN NMGIVFGPNI FKSRPDSPNI
     FSEAKYSNES VSFLISNYLN VFPDLEIPIL GTETNTEENE LLNNNNNNNN VIMPTTTTTT
     TSASSSILPT DSSNNNGGGS ASSPVTKSIP LSSIGSSSTS PIISPSSSSS SSPIVGTNLT
     TGSIHSTSPT PFSLLATTTS TTTTNSNKVN SIINSTSQSK SQLLPIHPSL LDTNQMIERV
     EGNPLSQMKR KDFSITHHLS TKLQKTKHFR KEEIWDCFLI LKVSGNLVNV KNSTTTTTTS
     TSTSTSTSTS TSTSSTTTNQ PNSITQSNSA SNNSLINNGK IKKSTTNLIS QSNSQSSLQL
     NQTNSNNNNI VTLTPVYILI TSQNVFFFDT RIYNIQYILP HSRLKEISVD VVNKGLFSIL
     DGESHKLSFF LVPRPRVIDL LVRSLERGRA IAKLTNKSLA SLQSRKFPLL ESNSGAGGTS
     NFGKLPESRP VFESLAQNGF TELDVWEGTV DLLEVVKKFH HILIPSADQS KCVVEFLLPA
     IPEFKGIYRK SYKLDSKTTV YKIICLICEK AKLEPSKFLL RTLKGRTLFD NKSLGDFGLG
     TLFTSWQLRL IALESPESTG NFVVEFLMPD IPEFKGMQKK AIKVDAYQPL KRIMKGLCDK
     LKIPNHHYYH LIGPEGEVLG DNDVLSSIGL GIKYKTCKMK LAKKVFPVGK NPELDTPMVR
     SLVIDNIIGL AWSKIKDRHN ERIRLYCKQM LDYIVDQTFV EIAKAELVPK RVAMLGKNSR
     YEFYHALSLK EEEDMILMDI QGYKETVYQS RSIVPSEPDS SPNYPLYRQK LPTIRGVGPI
     NSIRDIKVNS AKNNFLSELK DNNKQQQQQQ IGNTNDEHTI KPSQRIKYIA PTPVLNNPNS
     IVQLLALKPG ASKLVEQLKN RMTITTSKIN IFDVEDLVPK NSPVLSRKSY KL