GACGG_DICDI
ID GACGG_DICDI Reviewed; 1203 AA.
AC Q54VW7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Rho GTPase-activating protein gacGG;
DE AltName: Full=GTPase activating factor for raC protein GG;
GN Name=gacGG; ORFNames=DDB_G0280093;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AAFI02000035; EAL67273.1; -; Genomic_DNA.
DR RefSeq; XP_641238.1; XM_636146.1.
DR AlphaFoldDB; Q54VW7; -.
DR SMR; Q54VW7; -.
DR STRING; 44689.DDB0233849; -.
DR PaxDb; Q54VW7; -.
DR EnsemblProtists; EAL67273; EAL67273; DDB_G0280093.
DR GeneID; 8622369; -.
DR KEGG; ddi:DDB_G0280093; -.
DR dictyBase; DDB_G0280093; gacGG.
DR eggNOG; KOG1453; Eukaryota.
DR HOGENOM; CLU_270576_0_0_1; -.
DR InParanoid; Q54VW7; -.
DR OMA; EVFVWGN; -.
DR PRO; PR:Q54VW7; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 2.130.10.30; -; 2.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00415; RCC1; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF50985; SSF50985; 1.
DR PROSITE; PS50012; RCC1_3; 2.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; GTPase activation; Reference proteome; Repeat.
FT CHAIN 1..1203
FT /note="Rho GTPase-activating protein gacGG"
FT /id="PRO_0000380202"
FT REPEAT 52..104
FT /note="RCC1 1"
FT REPEAT 106..148
FT /note="RCC1 2"
FT REPEAT 155..204
FT /note="RCC1 3"
FT REPEAT 206..255
FT /note="RCC1 4"
FT REPEAT 257..298
FT /note="RCC1 5"
FT REPEAT 299..359
FT /note="RCC1 6"
FT REPEAT 361..410
FT /note="RCC1 7"
FT DOMAIN 381..594
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 316..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 649..679
FT /evidence="ECO:0000255"
FT COILED 995..1078
FT /evidence="ECO:0000255"
SQ SEQUENCE 1203 AA; 135060 MW; 9E6F3361A82EBD46 CRC64;
MTKKSQENIS LPQGVLYCWG DKFSGKPTFN PLIPNICFMD NGYNHSLALT ETGELYGWGD
NRHHQLSSNK AITSIDKPIK IQVIPNQRVK SISCGGNFSA AIMENGLLYV WGTLIEGGKC
TESPTKVDLL KGVTCVSIGI NHCAVVADSP TTPEKRSVYT WGTNRKGQLG VVGDSITNAP
RRVTLGSKAI SVCCGEEFTA AIVEGNEVFV WGYNKSRQIC SNNSDEIISI PVKPFLGRDI
VELSCTKNYI AARSGVGNVC VWGSNEQVCR IGDDKFINFP NKIKQISAST SHILVLSEKG
EIFSWGNSED NQLSHKLDVN SSPNINSSSG TTTPTTNTTT TTKKSTLQFN NVYQLEGRNV
LSVYSWGKSS GAIIEPGNFR VDIAESMRRK DNIGSPAPLF FRKLVNYLRG ENSKAEGLFR
LSGSMARCDD LEKRLDSNEI FPINKYEPYD AADIIKRYLK TLPEPLLTTQ LCQKYEKDIL
NFHNNNINSN SNSSNPNNNN NNNNNNDKIE NLILEWIEKL PLENRQLLIY LLSFLQEISY
SQIKYQKQNA MGEKNLAIVF APNILTRGEI GNDEIVEDMI RLLPTIMKQY PLMEDLIIID
QAQQCLRGSR IPYIIDHWIR VTKERETANN SLFKPEIIKT IINSIVECTL EIKNNQNNQN
NQKENNNNNN NINNSNNNNT NNTNISPTTL SPSTLSSSQQ QQSTPSSLTS SPSPSQRNSL
STGNIANSLS LSSNALFSPN FLSSSKDGNN INNNNNNNNN NNNNNNNNNS SNSSSSSGSS
LSSSPNLSPT IVNRSGYSLS FSGGTPSSRD SSVNNLLNTS GGAIQSIQRQ FANSGSSSNN
NNSNNSPSLI GSNSSPALTF SNSSGNLIET TKLYEKVLAL ILSPVLPIGS IMKVLPSIFE
LDTNNDLFIR LLTTIKLVRT VRSNLDEFIQ QQLVMIKEIN QCSQFIDKAK QLNENVESVI
TDLLYVDESI KYWKQVQPLI QLYSQQIQSY FKWWFDLLEK SMTETEEKLF RAKKEFDKLE
TEKTKLEKQL NHLNSVTLET TDEQILLKKQ FDQWCLINQI ENCSRKIEIS NQNLSRVNHD
YCSIQSHFEA FKPHLLIVQE FVSIILKSVS LYIEKLDQIK SNTLQMFPQY FNAYIELIFT
HHHEIKQQQQ LSIIKSLAHS ITLQHQLLFI ENVNQSKYQI SLELETKFNS LKRVILENLK
DSR
