GACG_DICDI
ID GACG_DICDI Reviewed; 1312 AA.
AC Q54QB9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Rho GTPase-activating protein gacG;
DE AltName: Full=GTPase activating factor for raC protein G;
GN Name=gacG; ORFNames=DDB_G0283955;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AAFI02000058; EAL65465.1; -; Genomic_DNA.
DR RefSeq; XP_638825.1; XM_633733.1.
DR AlphaFoldDB; Q54QB9; -.
DR STRING; 44689.DDB0233879; -.
DR PaxDb; Q54QB9; -.
DR EnsemblProtists; EAL65465; EAL65465; DDB_G0283955.
DR GeneID; 8624349; -.
DR KEGG; ddi:DDB_G0283955; -.
DR dictyBase; DDB_G0283955; gacG.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_260635_0_0_1; -.
DR InParanoid; Q54QB9; -.
DR OMA; PLEHKKS; -.
DR PRO; PR:Q54QB9; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0043326; P:chemotaxis to folate; IMP:dictyBase.
DR GO; GO:1905303; P:positive regulation of macropinocytosis; IMP:dictyBase.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0035020; P:regulation of Rac protein signal transduction; IBA:GO_Central.
DR GO; GO:1903013; P:response to differentiation-inducing factor 1; HDA:dictyBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..1312
FT /note="Rho GTPase-activating protein gacG"
FT /id="PRO_0000380201"
FT DOMAIN 1030..1212
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 52..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1209
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1312 AA; 147049 MW; 51D5A52DC58FC5C4 CRC64;
MASIFLNKKT IETNNFIFND NRPKNIKIVD KIKSSTVEFF HSIQKHIQQV KVENNNNNNN
NNNNSENNKY KRSQSEENIN NYIQNHFNPP QPQKKRNILF IFQNLINSGN SNNNNSSNSS
CNSTPSTSPS STPRSTNSPR STYSPRNNNN NFTESSSDNQ QFDITFNMVV EKERVILTVK
VPEVGLTKKI LFDKVETIKD AILLVIEKLP PGCLDASEYN LFLPQKNQWC KIDSRFSKYQ
FKENQEIEFK KDSRGGVSHM LSNVGNLLTR PYRTIYIKLP EIVTVGTLPP LQINGQIGDL
PSLNNSLNNS LNNISSSSSG GTGGGSGTTA AATGSSLSNS NSNSNLQNSQ SANNSPIIHR
RRTSSFSYDP NIHHSSLTHS NSNSNLISTN TSSIGNSAPS PTTLGSKPFS IPKLNLTENN
LNNSSSTSSS PRNNGNEVIQ SSSSTSSPRV NAPPPLEHKK SFLNIIGISP RGTNRERSSS
TNSLNNSTSS LKSSNNNILQ QQQQQQQHYD SAPTTPRNFG TFVRTQQLQN QQQQLQQQES
IEAFDFEDDS TLGEVLNKIC TRYQYIEKDL LEDYSLITKD GLWFVDRNKT ITELGLKHMD
EVEFKRMTQK VKVVFLNKEI VLNFNPSDTL KEINYKIIVH YLPSLIKLSR SNSILSSSSS
SIFLNHQSSS SSNSSSSPSQ SYRSSLSLEP LVISDLENSQ ILSNTPTITT VGNHQILNLQ
QQQNKQRSYS DASPLSFSKD YTSEISNHQQ QNIENHINRR KNSISTNPLT NSGNIANNNN
NNNNNKDKDD NNNNNNNNNN NNNNNNNNNN NNNNNNIASS TDTIQSNSST GSLGSNNNIA
FSIQQNRYPI PDNLVEFKDF KLHLSGTKNQ NPNINQKFDM LLDERRTLSS FNFWNNIKLH
FKNSSKSLHS DSKRVAPTLP FYLQIESVEQ FSVSHILELE GTLLISDILK SFNRLLLNNE
NIKINDPLDE YGLFFNTVNN GNREGLSYGS SIYLDPYKTL SHYPMIEPLD KLMFKRTNTI
FGVDPNTIVS KIDPITGFNI PCLLLDLKQK FIELDGFSIE GIFKTNNYYD LTFTEIIKEI
ENGTLLTSNN PNVDAIGIAC FIKRWFSKLP KKICSLLDDE TLLYASTQES TAEASLDSIP
QPYRSLLLWL VRFLSEVSQS AYTNKCSAKI LAIVIAPNLI SISPNNNNNN KENNDHHHHH
HHHHNSHHHR DNNNNNSNNN SSTTPTSSSV GKYTSLEKLH QCTLFLRNLI KLKLRENGFL
PISTSSISIS NSHNSSSFIS MTGTSETSIH SSNSPISSSI SRSPSLTDIV EE
