GACHH_DICDI
ID GACHH_DICDI Reviewed; 1523 AA.
AC Q86L99; Q55A58;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Rho GTPase-activating protein gacHH;
DE AltName: Full=GTPase activating factor for raC protein HH;
GN Name=gacHH; ORFNames=DDB_G0272080;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AAFI02000007; EAL71401.1; -; Genomic_DNA.
DR RefSeq; XP_645335.1; XM_640243.1.
DR AlphaFoldDB; Q86L99; -.
DR STRING; 44689.DDB0233840; -.
DR PaxDb; Q86L99; -.
DR PRIDE; Q86L99; -.
DR EnsemblProtists; EAL71401; EAL71401; DDB_G0272080.
DR GeneID; 8618297; -.
DR KEGG; ddi:DDB_G0272080; -.
DR dictyBase; DDB_G0272080; gacHH.
DR eggNOG; KOG0379; Eukaryota.
DR eggNOG; KOG4271; Eukaryota.
DR HOGENOM; CLU_247641_0_0_1; -.
DR InParanoid; Q86L99; -.
DR OMA; ETQLQCG; -.
DR PRO; PR:Q86L99; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 2.120.10.80; -; 2.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF117281; SSF117281; 2.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; GTPase activation; Kelch repeat;
KW Reference proteome; Repeat.
FT CHAIN 1..1523
FT /note="Rho GTPase-activating protein gacHH"
FT /id="PRO_0000380204"
FT REPEAT 30..76
FT /note="Kelch 1"
FT REPEAT 83..133
FT /note="Kelch 2"
FT REPEAT 135..184
FT /note="Kelch 3"
FT REPEAT 335..384
FT /note="Kelch 4"
FT REPEAT 386..441
FT /note="Kelch 5"
FT REPEAT 443..496
FT /note="Kelch 6"
FT DOMAIN 1233..1411
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 161..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1006..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1425..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 690..729
FT /evidence="ECO:0000255"
FT COILED 812..840
FT /evidence="ECO:0000255"
FT COILED 1151..1228
FT /evidence="ECO:0000255"
FT COMPBIAS 1006..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1081
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1523 AA; 166907 MW; 845811DCFBC52894 CRC64;
MSWSSIKLSR LPDATISVWG HTATISGEKD IVIFGGFDFC IEKPTNTTYI LHTSQTNGLT
KPSVSGSLPP PIYGHSSTQV GRKMFVFGGS LQDNVQVNDM YQFNTSNYSW SKPRPMGEPP
IPRYGHSASL IYDNYILIFG GNNTKSSKPL NDIHIFNTER NSWTKPSSNS STGEIIFNPH
DISPRSSTTT PTHQSVNGSN SNSSSSSRVR SATISSHNNS PIVMPLNNNN NNNNNSNNSN
NSNNNGGGSP MTTPPTLQQL HLSQLMANGI GMGGSISNGN SDSPPLTPSM MALESSMLNG
FKSPLSLSQR LLRSGFRSSP PSARYFHSCS VINGKAFIFG GYNGTTLLND LYILNIESME
WICPHTKGDL PTPRAGHTSI AIGSRLFIFG GTIEGDPSSS NAHCDNDLYM FEPELNYWTL
LKTSGTLPSP RTGHVCLPIS SKILIIGGSD AILNNKLKLS NTYHSLETLK LDFSHYSRGG
SGGGSNNNII IHPITSSNST SSNSIITNYL PHLKPRSSSN SGGGGGSITN TPTTSSLHIK
DNSASPSPLT PRSIARNSPK SSIFHDNINN NSNNNLLNTL QEASKFELSP GTPKSIRGID
SLSSVSLTQS IDRNGGSGGG SGGGNGVVSN DRGEFLRHYT TQSILINKNN NNNNNNNSGG
SNLSISSNSG SNNSINSNDG LVLQCSTPLC IKKYNSLKDS YLELKQKYQE EREKRLELEK
ELERYRLSSP ITSASSLVDT LSSPNNLNIN SNNSTTTTTT TTTTTTTPIP LSTSNNNNNN
NNNSTLTVQD QVTTSKQILE IYEDIYNLWG YYEKRVKWKE NTEKEANQQL EVIKSKIDLF
TSMVGLENHF SFNDDTKSCC SENINGDHNQ QQQQQQQQNP QFQIDDNISE TNSQISEPAL
IHETLTPRKS RENSVHHSRS VSNPIPLLSQ IVKQSKSGDS TLTVPQQLHS SHNNLIQLAS
ISTPQKPPQQ PQQQQQQQPP QENGKEPSKS TQKIFKLLIS KKNRASGHFK LSSSNESSNS
EETTPTFSNN PNLINDEDDD SQQHQQQTNI GSNSISNINT SNSTTSLSSS VSSTSLQTQE
EFEASERSKQ KKRLGKALKQ MINKDRQLKE TAAAALAVSN SNGNLGGGGG GGSINGTTNV
SGNGANNLGG LVLTSDKEKE KLEKEREKSE RIEREKQEKE REKLEKEREK SERIEREKLE
KAEKERLEKE KIEKEKLEKK HKKIKGLFGA KSSNKESLPF RRDVIEKVIN HLRENSLDTE
GIFRLSGNME SVRGIVKSFA HGEPNLSFEV HNISNALKHY LRSLDPPLIP YEFFLMLLDA
RKNEDAETIR NIFWKIPSDN RVVLTLLVDL MVKISENSNV NKMNSKNLSI VFGPTILKPR
TPTLDRMALM TETQLQCGII QTFIEDFHYI FSEFPTSGPK SFLGDDDYDS SSFGSNNTPS
SHSPHSSSPT LNPAVTTTTT TTTTTNTTTT TNTTTTPTSA TISPNIIQTN NCDSALCTPT
TLSSTAAIIQ SNNNNRTDSN RNN
